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Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts
(Pergamon-Elsevier B.V. Ltd, 2012-01-01)
Cytokines produced by inflammatory or resident mesenchymal cells play important modulatory roles in the pathogenesis of inflammation induced bone loss. In the present study, the effects of IL-4 and IL-13 on the expression ...
Smoking modulates interferon-gamma expression in the gingival tissue of patients with chronic periodontitis
(Blackwell PublishingOxfordInglaterra, 2006)
Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss
(2011)
p38 mitogen-activated protein kinases (MAPKs) are critical for innate immune signaling and subsequent cytokine expression in periodontal inflammation and bone destruction. In fact, previous studies show that systemic p38 ...
Activation of Shc1 allows oncostatin M to induce RANKL and osteoclast formation more effectively than leukemia inhibitory factor
(2019-01-01)
Background and Purpose: The gp130 family of cytokines signals through receptors dimerizing with the gp130 subunit. Downstream signaling typically activates STAT3 but also SHP2/Ras/MAPK pathways. Oncostatin M (OSM) is a ...
Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+and CCR5+in RANKL+ cell migration throughout experimental periodontitis in mice
(ELSEVIER SCIENCE INC, 2010)
Periodontal disease (PD) is characterized by the inflammatory bone resorption in response to the bacterial challenge, in a host response that involves a series of chemokines supposed to control cell influx into periodontal ...
Differential cytokine expressions affect the severity of peri-implant disease
(Wiley-blackwell Publishing, IncMaldenEUA, 2009)
Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease
(2020-11-11)
Periodontal disease (PD) is a prevalent inflammatory disease with the most severe consequence being the loss of the alveolar bone and teeth. We therefore aimed to evaluate the effects of telmisartan (TELM), an angiotensin ...
Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model
(Amer Acad Periodontology, 2018-04-01)
Background: Testosterone is known to affect bone in physiological and pathological conditions. The purpose of this study is to evaluate the role of testosterone in experimental periodontal disease in rats. Methods: In this ...