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The serine protease homolog, scarface, is sensitive to nutrient availability and modulates the development of the drosophila blood brain barrier
(Soc. Neuroscience, 2021)
The adaptable transcriptional response to changes in food availability not only ensures animal survival but also lets embryonic development progress. Interestingly, the CNS is preferentially protected from periods of ...
Nanoparticle-and liposome-carried drugs: New strategies for active targeting and drug delivery across blood-brain barrier
The blood-brain barrier (BBB), the unusual microvascular endothelial interface between the central nervous system (CNS) and the circulatory system, is a major hindrance to drug delivery in the brain parenchyma. Besides the ...
Reversible Demyelination, Blood-Brain Barrier Breakdown, and Pronounced Neutrophil Recruitment Induced by Chronic IL-1 Expression in the Brain
(American Society of Investigative Pathology, 2004-11)
Interleukin-1 (IL-1) expression is associated with a spectrum of neuroinflammatory processes related to chronic neurodegenerative diseases. The single-bolus microinjection of IL-1 into the central nervous system (CNS) ...
A Zika virus primary isolate induces neuroinflammation, compromises the blood-brain barrier and upregulates CXCL12 in adult macaques
(International Society of Neuropathology, 2023)
Brucella abortus traverses brain microvascular endothelial cells using infected monocytes as a Trojan horse
(Frontiers Media S.A., 2018-06)
Neurobrucellosis is an inflammatory disease caused by the invasion of Brucella spp. to the central nervous system (CNS). The pathogenesis of the disease is not well characterized; however, for Brucella to gain access to ...
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment
(2021-10-01)
Gliomas are primary brain tumors originating from glial cells, representing 30% of all Central Nervous System (CNS) neoplasia. Among them, the astrocytoma grade IV (glioblastoma multiforme) is the most common, presenting ...
Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation
(ELSEVIER SCIENCE INC, 2010)
Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating disease of the human central nervous system (CNS). Most of the knowledge about the pathogenesis of MS has been derived from murine models, such as ...