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Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi
(Public Library of Science, 2018-09)
Background: Drugs currently used for the treatment of Chagas’ disease, nifurtimox and benznidazole, have a limited effectiveness and toxic side effects. With the aim of finding new therapeutic approaches, in vitro and in ...
Purification of the antichagasic benznidazole from the commercial preparation Rochegan®: characterization of inclusion complexes with β-cyclodextrinPurificación del antichagásico benznidazol a partir del preparado comercial Rochagan®: caracterización de los complejos de inclusión con β-ciclodextrina
(Corporación Universitaria Autónoma del Cauca, 2018-08)
El Chagas es una enfermedad endémica del continente americano cuyo agente etiológico es el Trypanosoma cruzi. Actualmente, no hay una vacuna profiláctica para esta enfermedad o un tratamiento totalmente eficaz ´ para los ...
Old Yellow Enzyme from Trypanosoma cruzi exhibits in vivo Prostaglandin F2α synthase activity and has a key role in parasite infection and drug susceptibility
(Frontiers Media SA, 2018-03)
The discovery that trypanosomatids, unicellular organisms of the order Kinetoplastida, are capable of synthesizing prostaglandins raised questions about the role of these molecules during parasitic infections. Multiple ...
Toxicidade de fármacos nitrofurânicos
(2008-12-01)
During the structural designing of new drugs, it is possible predict the influence of specific chemical groups on pharmacological activity. Among these, the nitro group has potential antiparasitic activity, being present ...
Toxicidade de fármacos nitrofurânicos
(2008-12-01)
During the structural designing of new drugs, it is possible predict the influence of specific chemical groups on pharmacological activity. Among these, the nitro group has potential antiparasitic activity, being present ...
Clomipramine and Benznidazole act synergistically and ameliorate the outcome of experimental Chagas disease: In vivo and in vitro assessments
(American Society for Microbiology, 2016-06)
Chagas disease is an important public health problem in Latin America, and its treatment by chemotherapy with benznidazole (BZ) or nifurtimox remains unsatisfactory. In order to design new alternative strategies to improve ...
Evaluación de la actividad tripanocida de la serie 3-aril cumarinas y sus complejos de inclusión con β-ciclodextrina en combinación con benznidazol
(Universidad de Chile, 2022)
La enfermedad de Chagas o Tripanosomiasis americana es causada por el parásito protozoario Trypanosoma cruzi afectando aproximadamente a 18 millones de personas en todo el mundo, generando un problema importante de salud ...