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Application of computer-aided drug repurposing in the search of new cruzipain inhibitors: discovery of amiodarone and bromocriptine inhibitory effects
(American Chemical Society, 2013-06)
Cruzipain (Cz) is the major cystein protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. From a 163-compound dataset, a 2D-classifier capable of identifying Cz inhibitors was obtained and ...
Identification and human pharmacokinetics of dihydroergotoxine metabolites in man: Preliminary results
(John Wiley & Sons LtdChichesterInglaterra, 2008)
A influência da redução farmacológica da prolactina na responsividade de machos adultos de sagui à vocalização de filhotes recém-nascidos
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicina, 2017-12-08)
Parental care is described in the literature as a form of investment that includes all parenting activities directed to offspring, in order to ensure the survival and growth of offspring. In mammals, the mother appears as ...
Drugs commonly associated with weight change: Umbrella systematic review and meta-analysis (Protocol)
(BioMed Central, 2012)
Background: Many drugs and treatments given to patients for various reasons affect their weight. This side effect is of great importance to patients and is also a concern for the treating physician because weight change ...
Pharmacotherapy for sleep bruxism
(Wiley-Blackwell, 2014-01-01)
BackgroundSleep bruxism is an oral activity characterized by involuntary teeth grinding or clenching during sleep. Several forms of treatment have been proposed for this disorder, including behavioural, dental and ...
Bromocryptine restores angiotensin II response in pituitary hyperplasia
(Elsevier Ireland, 2000)
Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility
(Endocrine Society, 2012-12)
Female infertility is often associated with deregulation of hormonal networks, and hyperprolactinemia is one of the most common endocrine disorders of the hypothalamic-pituitary axis affecting the reproductive functions. ...