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Integrating stress signals at the endoplasmic reticulum: the bcl-2 protein family rheostat
(ELSEVIER SCIENCE BV, 2011)
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
(ELSEVIER, 2008-01)
Apoptosis is essential for maintenance of tissue homeostasis and its deregulation underlies many disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death, comprising ...
The role of the multi-drug resistance 1, p53, b cell lymphoma 2, and bcl 2-associated X genes in the biologic behavior and chemotherapeutic resistance of canine transmissible venereal tumors
(2019-12-01)
Background: Canine transmissible venereal tumors (CTVTs) generally have different cytomorphologic subtypes and phases of progression. Some tumors have variable biologic behavior including a progressive increase in tumor ...
Effects of long-term adrenalectomy on apoptosis and neuroprotection in the rat hippocampus
(2006)
Reduction in corticosterone by acute adrenalectomy (5 d) promotes apoptosis in dentate gyrus (DG) granular neurons, an effect concomitant with variations in the expression of the Bcl-2 gene family implicated in apoptotic ...
Role of charged residues in the protein membrane and protein-protein interaction during activation of the mitochondrial pathway of apoptosis
(Fundación Revista Medicina, 2017)
The intrinsic pathway of apoptosis is activated by signals of cellu-lar stress and regulated at the mitochondrial level. Such regulationis carried out by members of the Bcl-2 protein family (B leukemiacell lymphoma 2). ...
Bcl-2-like protein-10 increases aggressive features of melanoma cells
(Open Exploration, 2022-01)
Aim: B-cell lymphoma-2 (Bcl-2)-like protein-10 (Bcl2L10) is the less studied member of Bcl-2 family proteins, with the controversial role in different cancer histotypes. Very recently, Bcl2L10 expression in melanoma tumor ...
Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats
(Wiley, 2011-05)
PCOS (polycystic ovary syndrome) is a heterogeneous disease characterized by hyperandrogenaemia, hirsutism, oligo- or amenorrhea, insulin resistance and anovulation. The aim of the present study was to evaluate if the ...