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Nuclear localization of β-catenin and expression of target genes are associated with increased Wnt secretion in oral dysplasia
(Elsevier, 2019)
Objectives: To evaluate the localization of β-catenin in oral dysplastic cells, the expression of target genes upregulated
in oral dysplasia, and the role of Wnt ligands in these events.
Materials and methods: Subcellular ...
E-cadherin and beta-catenin Loss of Expression Related to Bone Metastasis in Prostate Cancer
(LIPPINCOTT WILLIAMS & WILKINS, 2010)
Objectives: E-cadherin and beta-catenin are adhesion molecules responsible for the maintenance of normal epithelial cell phenotype. A disturbance in epithelial cell adhesion, which leads to a more invasive and metastatic ...
Altered beta-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip
(ELSEVIER SCIENCE INC, 2011)
beta-Catenin is a bifunctional protein related to cell adhesion and gene transcription when activated by Wnt pathway. Altered expression of beta-catenin was related to loss of differentiation, more aggressive phenotype, ...
Estrogen receptor beta (ER beta) mediates expression of beta-catenin and proliferation in prostate cancer cell line PC-3
(Elsevier Ireland Ltd, 2016)
The aim of the present study was to characterize the mechanism underlying estrogen effects on the androgen-independent prostate cancer cell line PC-3. 17 beta-estradiol and the ER beta-selective agonist DPN, but not the ...
Attenuation of the Wnt/b-catenin/TCF pathway by in vivo interferon-a2b (IFN-a2b) treatment in preneoplastic rat livers
(Taylor & Francis, 2010)
Wnt/β-catenin/T cell factor (TCF) pathway is activated in several types of human cancers, promoting cell growth and proliferation. Forkhead box containing protein class O (FOXO) transcription factors compete with TCF for ...
Interferon-a2b and transforming growth factor-b1 treatments on HCC cell lines: are Wnt/b-catenin pathway and Smads signaling connected in hepatocellular carcinoma?
(Elsevier Inc, 2011-12)
Wnt/b-catenin pathway is often dysregulated in hepatocellular carcinoma (HCC). Activated b-catenin accumulates in the cytosol and nucleus and forms a nuclear complex with TCF/LEF factors like TCF4. Interferon-a (IFN-a) has ...
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease
(Blackwell Publishing Ltd, 2016)
© 2016 International Society for Neurochemistry Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's ...
Simvastatin modulates β-catenin/MDR1 expression on spheres derived from CF41.Mg canine mammary carcinoma cells
(Polish Academy of Sciences, 2018)
© 2018 Polish Academy of Sciences. All rights reserved. The presence of cancer stem-like cells (CSC) within canine mammary tumors, may explain partly local recurrence and spreading, since their ability to resist conventional ...