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Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?
(2016)
The structural homeostasis is challenging for neurons, whose axons extend up to meters in large animals, and the axoplasmic mass reaches over a thousand times that of the cell body. Thus, the protein demand may overcome ...
Gangliosides in Axon Stability and Regeneration
(Elsevier, 2018)
Gangliosides are a family of sialic acid-containing glycosphingolipids highly expressed in the nervous system of vertebrates. Over the last 25years, research has unmasked several of their neurobiological functions but the ...
The axonal endoplasmic reticulum: one organelle many functions in development, maintenance, and plasticity
(Wiley, 2018)
The endoplasmic reticulum (ER) is highly conserved in eukaryotes and neurons. Indeed, the localization of the organelle in axons has been known for nearly half a century. However, the relevance of the axonal ER is only ...
Anti-glycan antibodies halt axon regeneration in a model of Guillain Barrè Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2
(Academic Press Inc Elsevier Science, 2016-04)
Several reports have linked the presence of high titers of anti-Gg Abs with delayed recovery/poor prognosis in GBS. In most cases, failure to recover is associated with halted/deficient axon regeneration. Previous work ...
Bursting the unfolded protein response accelerates axonal regeneration
(Medknow Publications, 2016)
Bursting the unfolded protein response accelerates axonal regeneration
(CIENCIAS, 2016)
Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system (PNS) is damaged. These pathological state are are associated with weakness, pain, and loss of motor and sensory control. More ...
Schwann Cell Exosomes Mediate Neuron–Glia Communication and Enhance Axonal Regeneration
(2016)
The functional and structural integrity of the nervous system depends on the coordinated action of neurons and glial cells. Phenomena like synaptic activity, conduction of action potentials, and neuronal growth and ...
Regeneración axonal posterior a lesiones traumáticas de médula espinal: papel crítico de galectina-1Axonal regeneration in spinal cord injury: a key role of galectin-1
(Medicina (Buenos Aires), 2014-05)
Al producirse una lesión de médula espinal (LME), un sinnúmero de proteínas inhibidoras de la regeneración axonal ocupan el sitio de lesión en forma secuencial. La primer proteína en llegar al mismo se conoce como semaforina ...
Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons
(Wiley, 2021-01)
Axonal outgrowth is a fundamental process during the development of central (CNS) and peripheral (PNS) nervous system as well as in nerve regeneration and requires accurate axonal navigation and extension to the correct ...
Mitochondrial function in spinal cord injury and regeneration
(SPRINGER BASEL AG, 2022)
Many people around the world suffer from some form of paralysis caused by spinal cord injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of the central nervous system (CNS), which in ...