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Characterization of aporphine alkaloids by electrospray ionization tandem mass spectrometry and density functional theory calculations
(2020-09-01)
Rationale: Aporphine alkaloids represent a large group of isoquinoline natural products with important roles in biological and biomedical areas. Their characterization by electrospray ionization tandem mass spectrometry ...
A possible structural determinant of selectivity of boldine and derivatives for the α1A-adrenoceptor subtype
(John Wiley and Sons Inc., 1996)
1 The selectivity of action of boldine and the related aporphine alkaloids, predicentrine (9-O-methylboldine) and glaucine (2,9-O-dimethylboldine) on α1-adrenoceptor subtypes was studied by examining [3H]-prazosin competition ...
New heterocyclic skeletons derived from the aporphine alkaloid boldine
(MARCEL DEKKER INC, 2002)
The abundant aporphine alkaloid (S)-(+)-boldine (1) was selectively nitrosated with sodium nitrite in acetic acid affording 8-nitrosoboldine (2) which was hydrogenated catalytically to give 8-aminoboldine (3). The latter ...
Aporphine and tetrahydroprotoberberine alkaloids from the leaves of Guatteria friesiana (Annonaceae) and their cytotoxic activities
(Sociedade Brasileira de Química, 2013)
Síntese totais de lisicamina e da (+-)-apomorfina via química de benzino
(Universidade Federal de São Paulo, 2016-04-29)
The benzyne chemistry have been successfully employed in several approches involving total syntheses of natural products and bioative substances. Thus, due to the considerable importance of 2-(trimethylsilyl)aryl triflates ...
E ffects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice
(Elsevier Science B.V., 2002-11-20)
(S)-(1)-boldine, an aporphine alkaloid displaying antioxidative and dopaminergic properties, and six of its derivatives (glaucine,
3-bromoboldine, 3-iodoboldine, 8-aminoboldine, 8-nitrosoboldine and 2,9-O,O9 -dipivaloylboldine) ...
Síntese totais convergentes de alcalóides aporfinoides empregando química de benzino
(Universidade Federal de São Paulo, 2014-01-08)
The chemistry of benzyne has been successfully employed in several approaches involving the total synthesis of natural products and bioactive substances. Thus, due to the considerable importance of 2-(trimethylsilyl)aryl ...
C-13-NMR ANALYSIS OF APORPHINE ALKALOIDS
(Pergamon-elsevier Science LtdOxfordInglaterra, 1979)
Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: Halogenation and D1 receptor selectivity
(Elsevier Ltd, 2005)
Halogenation of the aporphine alkaloid boldine at the 3-position leads to increased affinity for rat brain D1-like dopaminergic receptors with some selectivity over D2-like receptors. A series of 3-halogenated and ...