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Synergistic interactions of the anti‑casein kinase 2 CIGB‑300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models
(Spandidos Publications, 2014-07)
CIGB‑300 is a novel clinical‑stage synthetic peptide that impairs the casein kinase 2 (CK2)‑mediated phosphorylation of B23/nucleophosmin in different experimental settings and cancer models. As a single agent, CIGB‑300 ...
Avaliação da ação de nanoemulsões vinculadas à terapia fotodinâmica em modelo de câncer de mama metastático murino 4T1
(Universidade Estadual Paulista (Unesp), 2022-01-20)
O câncer de mama constitui um grave problema de saúde pública, não só pela elevada incidência e mortalidade, como pelo tratamento muitas vezes ineficaz. Diferentes sistemas nanoestruturados vêm sendo implementados a fim ...
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
(BioMed Central (BMC), 2022)
Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts
(2022-01-01)
The objective of the present study was to evaluate the action of the crude hydroalcoholic extract of Piper cubeba fruits and isolated lignans (cubebin, dihydrocubebin, ethylcubebin, hinokinin and methylcubebin) on head and ...
Evaluation of melatonin effect on human breast cancer stem cells using a threedimensional growth method of mammospheres
(2017-01-01)
Background: The high rates of women's death from breast cancer occur due to acquired resistance by patients to certain treatments, enabling the recurrence and/or tumor growth, invasion and metastasis. It has been demonstrated ...
Trends of cancer incidence and mortality in Cali, Colombia. 50 years experience.
(2013-07-08)
Purpose :The Population-based Cancer Registry of Cali
aims to report all new cases in permanent residents
within the limits of the city of Cali. Time trends of cancer
incidence and mortality are described. The registry ...
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
(Elsevier Science, 2012-03)
Background: Traditional cancer therapy can be successful in destroying tumors, but can also cause dangerous side effects. Therefore, many targeted therapies are in development. The transferrin receptor (TfR) functions in ...
Brazilian natural dietary components (annatto, propolis and mushrooms) protecting against mutation and cancer
(Hodder Arnold, Hodder Headline Plc, 2014)
Melatonin as a promising agent to treat ovarian cancer: Molecular mechanisms
(2017-10-01)
Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, and most patients develop chemoresistance after first-line treatments. Despite recent advances, the 5-year relative survival is ~45% for all ...
The pharmacological treatment of obesity: A historical perspective
(Academia Nacional de Medicina venezolana., 2022)