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The cDNAs coding for the α- and β-subunits of Xenopus laevis casein kinase II
(1992)
Using a λgt10 cDNA library obtained from Xenopus laevis oocytes and probes derived from the known sequences of the human and Drosophila genes, a cDNA coding for the α-subunit of the X. laevis casein kinase II was isolated. ...
ArrayPitope: Automated analysis of amino acid substitutions for peptide microarray-based antibody epitope mapping
(Public Library of Science, 2017-01)
Identification of epitopes targeted by antibodies (B cell epitopes) is of critical importance for the development of many diagnostic and therapeutic tools. For clinical usage, such epitopes must be extensively characterized ...
Dissection of a beta-barrel motif leads to a functional dimer: the case of the intestinal fatty acid binding protein
(Wiley, 2009-12)
A lingering issue in the area of protein engineering is the optimal design of beta motifs. In this regard, the framework provided by intestinal fatty acid binding protein (IFABP) was successfully chosen to explore the ...
Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon
(Elsevier, 2011)
Population genetic analyses of bacterial genes whose products interact with host tissues can give new understanding of infection and disease processes. Here we show that strains of the genetically diverse gastric pathogen ...
Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists
(Public Library of Science, 2011)
CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis ...
High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifsJOURNAL OF BIOLOGICAL CHEMISTRY (PRINT)J BIOL CHEM (PRINT)
(AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017)
AFAL: a web service for profiling amino acids surrounding ligands in proteins
(2014)
With advancements in crystallographic technology and the increasing wealth of information populating structural databases, there is an increasing need for prediction tools based on spatial information that will support the ...