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Compartmentalization of antagonistic Ca2+ signals in developing cochlear hair cells
(National Academy of Sciences, 2018-02)
During a critical developmental period, cochlear inner hair cells (IHCs) exhibit sensory-independent activity, featuring action potentials in which Ca2+ ions play a fundamental role in driving both spiking and glutamate ...
Protein kinases in the photic signaling of the mammalian circadian clock
(Yale School of Medicine, 2019-06-27)
Circadian clocks drive biological rhythms in physiology and behavior, providing a selective advantage by enabling organisms to synchronize to the 24 h environmental day. This process depends on lightdark transitions as the ...
Efeitos cardiovasculares e renais da denervação seletiva das fibras sensoriais renais na Hipertensão Renovascular Experimental
(Universidade Federal de São Paulo (UNIFESP), 2019-07-25)
It is known that oxidative stress and increased renal sympathetic nervous activity (rSNA) play an important role in arterial hypertension (AH). Under physiological conditions, renal sympathetic fibers control renin release, ...
Luminance and chromatic signals interact differently with melanopsin activation to control the pupil light response
(Association for Research in Vision and Ophthalmology, 2016-08)
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin. These cells receive afferent inputs from rods and cones, which provide inputs to the postreceptoral visual pathways. It is ...
Laboratory experience for teaching sensory physiology
(American Physiological Society, 2009-05)
The major challenge in laboratory teaching is the application of abstract concepts in simple and direct practical lessons. However, students rarely have the opportunity to participate in a laboratory that combines practical ...
Ablation of primary afferent neurons by neonatal capsaicin treatment reduces the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury in cirrhotic rats
(ELSEVIER SCIENCE BV, 2008)
Primary sensory afferent neurons modulate the hyperdynamic circulation in Cirrhotic rats with portal hypertension.The stomach of cirrhotic rats is prone to damage induced by ethanol, a phenomenon associated with reduced ...
Role of the parasympathetic nervous system in cardioprotection by remote hindlimb ischemic preconditioning
(Wiley, 2013-02)
This investigation was designed to determine the participation of the vagus nerve and muscarinic receptors in the remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, and the femoral ...
Efferent innervation and function
(Oxford University Press, 2012)
Mechanosensory hair cells of the organ of Corti and vestibular end organs transmit information regarding either sound or body position and motion to the central nervous system by way of peripheral afferent neurons. In ...
Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats
(2017)
Spontaneous physical activity (SPA) describes activity outside of formal exercise and shows large interindividual variability. The hypothalamic orexin/hypocretin peptides are key regulators of SPA. Orexins drive SPA within ...
Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
(Cell Press, 2018-05)
Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded ...