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Promiscuous subunit interactions: A possible mechanism for the regulation of protein kinase CK2
(1998)
Protein kinase CK2 is a ubiquitous eukaryotic ser/thr protein kinase. The active holoenzyme is a heterotetrameric protein corn posed of catalytic (α and α') and regulatory (β) subunits that phosphorylates many different ...
Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling
(Springer, 2019)
Allostery is a basic principle that enables proteins to process and transmit cellular information. Protein kinases evolved allosteric mechanisms to transduce cellular signals to downstream signalling components or effector ...
A fluorometric method for the assay of protein kinase activity
(Academic Press Inc Elsevier Science, 2018-09-15)
Protein kinases constitute one of the largest protein families in nature. Current methods to assay their activity involve the use of radioactive ATP or very expensive reagents. In this work, we developed a highly sensitive, ...