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Effects of photodynamic therapy mediated by emodin in cervical carcinoma cells
(2021-09-01)
Cervical cancer is a worldwide public health problem, and improved selective therapies and anticancer drugs are urgently needed. In recent years, emodin has attracted considerable attention due to its anti-inflammatory, ...
Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A
(Int Inst Anticancer Research, 2017-03-01)
Monastrol and its analog oxomonastrol differ by replacement of the sulfur atom present in monastrol to an oxygen atom in oxomonastrol. Monastrol inhibits the mitotic kinesin family member 11 (EG5), which has been studied ...
Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies
(2011)
Hsp90 is a molecular chaperone involved in the stabilization of many oncoproteins that are required for the acquisition and maintenance of the so-called six major hallmarks of cancer cells. Various strategies have, therefore, ...
In vivo nanotoxicology of hybrid systems based on copolymer/silica/anticancer drug
(2015-05-26)
One of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ...
Incidence and risk of xerosis with targeted anticancer therapies
Background Many targeted therapies used in the treatment of cancer can lead to the development of xerosis, but the incidence and relative risk of xerosis have not been ascertained. Objective We conducted a systematic review ...
Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells
(Nature Publishing Group, 2016-03-02)
The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of ...
Mimosine and Cyclophosphamide: a Potential New Combination Therapy Used to Prevent Tumor Development
(INST TECNOLOGIA PARANACURITIBA-PARANA, 2013-08-02)
The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide ...
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development
(Brazilian Archives of Biology and Technology, 2012)
The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide ...
Phosphatidylserine lipids and membrane order precisely regulate the activity of Polybia-MP1 peptide
(2017-06-01)
Polybia-MP1 (IDWKKLLDAAKQIL-NH2) is a lytic peptide from the Brazilian wasp venom with known anti-cancer properties. Previous evidence indicates that phosphatidylserine (PS) lipids are relevant for the lytic activity of ...
Metal complexes as a possible anticancer therapy: a review of the literature
(Universidad de los AndesBiologíaFacultad de CienciasDepartamento de Ciencias Biológicas, 2021)
Cancer is still one of the groups of multifactorial diseases that causes more deaths worldwide. In fact, emerging resistance to traditional cancer treatments make necessary the analysis of new methods to treat cancer. One ...