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Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation
(Cell Press, 2018-03)
The inherent tendency of proteins to convert from their native states into amyloid aggregates is associated with a range of human disorders, including Alzheimer's and Parkinson's diseases. In that sense, the use of small ...
Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain
(e-Century Publishing, 2019)
Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
(2010)
Abstract
Background
Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ ...
Self-assembly and anti-amyloid cytotoxicity activity of amyloid beta peptide derivatives
(Nature Publishing Group, 2017-03)
The self-assembly of two derivatives of KLVFF, a fragment Aβ(16-20) of the amyloid beta (Aβ) peptide, is investigated and recovery of viability of neuroblastoma cells exposed to Aβ (1-42) is observed at sub-stoichiometric ...
In silico evidence of direct interaction between statins and β-amyloid
(Wiley-Liss Inc., 2019)
Molecular modulation of human α7 nicotinic receptor by amyloid-β peptides
(Frontiers Media S.A., 2019-02-08)
Amyloid β peptide (Aβ) is a key player in the development of Alzheimer’s disease (AD). It is the primary component of senile plaques in AD patients and is also found in soluble forms. Cholinergic activity mediated by α7 ...
Unraveling the β-AMYLOID clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPα, and class-A scavenger receptor
(Elsevier, 2019-12)
The mechanics of β-amyloid (Aβ) clearance by astrocytes has not been univocally described, with different mediators appearing to contribute to this process under different conditions. Our laboratory has demonstrated ...
Small Molecule Inhibitors of Lysozyme Amyloid Aggregation
(Springer, 2020)
A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain
(Frontiers, 2017-03)
The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble ...
Alzheimer's disease amyloid β-protein forms Zn2+-sensitive, cation- selective channels across excised membrane patches from hypothalamic neurons
(Biophysical Society, 1997)
We have previously shown that the 40-residue peptide termed amyloid β- protein (AβP[1-40]) in solution forms cation-selective channels across artificial phospholipid bilayer membranes. To determine whether AβP[1-40] also ...