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In vitro anti-echinococcal and metabolic effects of metformin involve activation of AMP-activated protein kinase in larval stages of Echinococcus granulosus
(Public Library of Science, 2015-05)
Metformin (Met) is a biguanide anti-hyperglycemic agent, which also exerts antiproliferative effects on cancer cells. This drug inhibits the complex I of the mitochondrial electron transport chain inducing a fall in the ...
Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration
(Nature Publishing Group, 2019-02)
Hepatocellular carcinoma (HCC) is a highly metastatic cancer with very poor prognosis. AMP activated kinase (AMPK) constitutes a candidate to inhibit HCC progression. First, AMPK is downregulated in HCC. Second, glucose ...
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
(2016)
Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
The Glp-1 Receptor Agonists Exenatide And Liraglutide Activate Glucose Transport By An Ampk-dependent Mechanism
(Biomed Central LtdLondon, 2016)
Resveratrol: mudança do padrão de sinalização da SIRT 1 e AMPK durante o processo de envelhecimento
(Universidade Federal de Minas GeraisUFMG, 2019-03-27)
Aging is primarily caused by the damage generated by free radicals (FR). The FR theory of aging postulates that reactions with these species are involved with agerelated disorders, such as cellular metabolic stress. ...
Avaliação de polimorfismos nos genes FOXO3A, AMPK EPOMC e sua relação com a obesidade mórbida
(Universidade Federal de Minas GeraisUFMG, 2013-02-18)
Morbid obesity (MO) is a metabolic disorder that affects people worldwide. Excessive fat accumulation in MO patients is frequently found to increase the risk for several co-morbidities, including cardiovascular disease and ...
Efeitos do exercício físico na expressão e atividade da AMPKα em ratos obesos induzidos por dieta rica em gorduraEffects of physical exercise in the Ampkα expression and activity in high-fat diet induced obese rats
(Sociedade Brasileira de Medicina do Exercício e do Esporte, 2009)
Papel da proteína quinase ativada por AMP (AMPK) em Trypanosoma cruzi
(Universidade Federal de São Paulo, 2021)
O Trypanosoma cruzi é um protozoário flagelado, causador da doença de Chagas. Durante o seu ciclo biológico o T. cruzi apresenta uma alta capacidade de adaptação ambiental, pois vive em diferentes hospedeiros em cada etapa ...
CNTF protects MIN6 cells against apoptosis induced by Alloxan and IL-1 beta through downregulation of the AMPK pathway
(Elsevier Science IncNew YorkEUA, 2011)
Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus
(Bentham Science Publishers, 2019-07)
Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives ...