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The polarized localization of lipoprotein receptors and cholesterol transporters in the syncytiotrophoblast of the placenta is reproducible in a monolayer of primary human trophoblasts
(2021-02)
Introduction: The uptake of low- and high-density lipoproteins (LDL and HDL) through the LDL receptor (LDLR) and the scavenger receptor class B type I (SR-BI) mediates maternal to fetal cholesterol transfer in syncytiotrophoblast ...
Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice
(WILEY, 2002)
Receptor-mediated endocytosis is one of the major mechanisms for uptake of lipoprotein cholesterol in the liver. Because Niemann-Pick C1 (NPC1) protein is a key component in the intracellular distribution of cholesterol ...
LXR activation increases the expression of GnRH AND αMSH in the rat hypothalamus in vivo
(Elsevier Science, 2018-01)
Liver X receptors (LXR) are important transcription factors involved in the regulation of carbohydrate and lipid metabolism. Recently, we described LXR receptors expression in the hypothalamus but their function in this ...
Asymptomatic Individuals With High Hdl-c Levels Overexpress Abca1 And Abcg1 And Present Mir-33a Dysregulation In Peripheral Blood Mononuclear Cells
(ELSEVIER SCIENCE BVAMSTERDAM, 2015)