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Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality
(American Society For Biochemistry And Molecular Biology, 2013-05)
Studies of post-mortem brains from Alzheimer disease patients suggest that oxidative damage induced by mitochondrial amyloid β (mitAβ) accumulation is associated with mitochondrial dysfunction. However, the regulation of ...
Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain
(Elsevier Science Inc, 2017-12)
The unfolded protein response (UPR) may be pathogenically related to Alzheimer's disease. Yet, the effects of chronic amyloid-β42 (Aβ42) accumulation and UPR activation upon neurotoxicity remain unclear. Here, we show that ...
Amyloid β peptide decreases α7 receptor potentiation
(Fundación Revista Medicina, 2017)
Amyloid β peptide (Aβ) is a key player in the development of Alzheimer disease (AD). Aβ is visible as the primary component of senile plaques in the brains of Alzheimer’s patients. Cholinergic activity mediated by human ...
Structural characterization of microcin E492 amyloid formation: Identification of the precursors
(2012)
Microcin E492 is a low-molecular weight, channel-forming bacteriotoxin that generates amyloid structures. Using electron microscopy and image processing techniques several structural conformations can be observed. Prior ...
Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures
(Oxford University Press, 2020-08-28)
The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. is there a role in Alzheimer's disease?
(2011)
Amyloid β-peptide (Aβ) is the main component of the amyloid plaques associated with Alzheimer's disease (AD). In the early steps of the disease soluble Aβ oligomers are produced. According to the current "amyloid hypothesis" ...
DETERMINACIÓN DE LAS CONCENTRACIONES DE AMILOIDE β40 Y AMILOIDE β42 EN EL LÍQUIDO AMINIÓTICO DE MUJERES EMBARAZADAS CON FETOS CON TRISOMIA 21
(Facultad de Medicina de la Universidad Central de Venezuela., 2022)