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Hepatocellular carcinoma and miRNAs: An in silico approach revealing potential therapeutic targets for polyphenols
(2022-05-01)
Background: Identifying innovative and effective therapeutic agents is imperative for treating hepatocellular carcinoma (HCC). Natural phytochemical compounds may be a feasible glimmer of hope as more than 8,000 phenolic ...
Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
(American Association for Cancer Research., 2019-05)
Purpose: Imaging mass cytometry (IMC) uses metal-conjugated antibodies to provide multidimensional, objective measurement of protein targets. We used this high-throughput platform to perform an 18-plex assessment of HER2 ...
MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies
(2022)
The MET gene, known as MET proto-oncogene receptor tyrosine kinase, was first identified to induce tumor cell migration, invasion, and proliferation/survival through canonical RAS-CDC42-PAK-Rho kinase, RAS-MAPK, PI3K-AKT-mTOR, ...
Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia
(Elsevier Ireland, 2017-01)
In androgenetic alopecia, androgens impair dermal papilla-induced hair follicle stem cell (HFSC) differentiation inhibiting Wnt signaling. Wnt agonists/antagonists balance was analyzed after dihydrotestosterone (DHT) ...
Role of astrocytic dysfunction in the pathogenesis of parkinson’s disease animal models from a molecular signaling perspective
(Hindawi, 2020)
Resumen: Despite the fact that astrocytes are the most abundant glial cells, critical for brain function, few studies have dealt with their possible
role in neurodegenerative diseases like Parkinson’s disease (PD). This ...
Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells
(Spandidos Publications, 2015-05)
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The ...
Low-Grade Myofibroblastic Sarcoma of the Oral and Maxillofacial Region: An International Clinicopathologic Study of 13 Cases and Literature Review
(Springer, 2023)
Low-grade myofibroblastic sarcoma (LGMS) represents an atypical tumor composed of myofibroblasts with a variety of histological patterns and with a high tendency to local recurrence and a low probability of distant metastases. ...
Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line
(2019)
Abstract
Background
Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). ...