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Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model
(Elsevier B. V., 2015)
Sildenafil (Viagra®) has recently been found to have a neuroprotective effect, which occurs through the inhibition of inflammation and demyelination in the cerebellum. However, the mechanism of action of sildenafil remains ...
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
(Elsevier, 2020-04)
Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed ...
Calcium Signaling Alterations, Oxidative Stress, and Autophagy in Aging
(Mary Ann Liebert, Inc, 2014-07-01)
Significance: Aging is a multi-factorial process that may be associated with several functional and structural deficits which can evolve into degenerative diseases. in this review, we present data that may depict an expanded ...
Impaired endocrine-metabolic homeostasis: Underlying mechanism of its induction by unbalanced diet
(Portland Press, 2018-04)
To characterize the intrinsic mechanism by which sucrose induces β-cell dysfunction. Normal rats received for 3 weeks a standard diet supplemented with 10% sucrose in the drinking water (high sucrose (HS)) with/out an ...
Prenatal stress promotes insulin resistance without inflammation or obesity in C57BL/6J male mice
(Taylor & Francis Ltd, 2021-09)
During gestation, stress exposure increases the risk of developing cognitive and physiological alterations in either the long or short term. Among them, metabolic alterations have been described. Adipose tissue is responsible ...
Hepatocellular carcinoma and miRNAs: An in silico approach revealing potential therapeutic targets for polyphenols
(2022-05-01)
Background: Identifying innovative and effective therapeutic agents is imperative for treating hepatocellular carcinoma (HCC). Natural phytochemical compounds may be a feasible glimmer of hope as more than 8,000 phenolic ...
Ordenamiento Territorial Rural (OTR)
(EEA Bariloche, INTA, 2012)
El OTR constituye una herramienta de gestión en el proceso de planificación del uso de la tierra.
“Se entiende por tal a un proceso de organización, armonización y administración consensuada de la ocupación y los usos de ...
Estresse oxidativo: avaliação in vitro da capacidade moduladora do Resveratrol em células da linhagem Neuro 2-A
(Universidade Federal de Minas GeraisUFMG, 2018-09-06)
Aging is a natural and physiological process that progressively compromises the individual's physical and cognitive status, increasing the risk of morbidities such as: cancer, cardiovascular diseases and mortality. It is ...
Efecto de la melatonina sobre la expresión de modificadores epigenéticos, microRNAs y la proliferación hipocampal en un modelo murino de privación de sueño
(Biblioteca Digital wdg.biblioUniversidad de Guadalajara, 2019-04-29)
Melatonin is a pleiotropic molecule that, after a short-term sleep
deprivation, promotes the proliferation of neural stem cells in the adult
hippocampus. However, this effect has not been observed in long-term
sleep ...
Metformin promotes autophagy in Echinococcus granulosus larval stage
(Elsevier Science, 2018-09)
Cystic echinococcosis is a neglected parasitic disease caused by the larval stage of Echinococcus granulosus for which an effective treatment is not yet available. Since autophagy constitutes a homeostatic mechanism during ...