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In vitro human umbilical vein endothelial cells response to ionic dissolution products from lithium-containing 45S5 bioactive glass
(MDPI, 2017-07-03)
Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a ...
Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis
(Elsevier Inc, 2019-05)
Vertebrate teeth are attached to the jawbones using a variety of methods but in mammals, a fibrous connection is the norm. This fibrous periodontal ligament (PDL) allows teeth to move in the jawbones in response to natural ...
Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage
(Company of Biologists, 2021-02-25)
The blastula Chordin- A nd Noggin-expressing (BCNE) center comprises animal-dorsal and marginal-dorsal cells of the amphibian blastula and contains the precursors of the brain and the gastrula organizer. Previous findings ...
Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression
(Amer Soc Investigative Pathology, Inc, 2006-12)
Proteolytic activity and remodeling of the extracellular matrix are important players in tumor progression. However, to date the role of the extracellular matrix in tumor regression remains unresolved. To address this, we ...
A novel function for Wnt signaling modulating neuronal firing activity and the temporal structure of spontaneous oscillation in the entorhinal-hippocampal circuit
(Elsevier Inc, 2015)
During early and late postnatal developments, the establishment of functional neuronal connectivity depends on molecules like Wnt that help the recently formed synapses to establish and consolidate their new cellular ...
MCAM knockdown impairs PPARγ expression and 3T3-L1 fibroblasts differentiation to adipocytes
(Springer, 2018-11)
We investigated for the first time the expression of melanoma cell adhesion molecule (MCAM) and its involvement in the differentiation of 3T3-L1 fibroblasts to adipocytes. We found that MCAM mRNA increased subsequent to ...
Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells
(Impact Journals, 2018-05-04)
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This ...
Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity
(American Society for Biochemistry and Molecular Biology, 2015-04)
Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization. Particularly, SM is associated ...
The UVB1 Vitamin D Analogue Inhibits Colorectal Carcinoma Progression
(Pergamon-Elsevier Science Ltd, 2016-10)
Vitamin D has been shown to display a wide variety of antitumour effects, but their therapeutic use is limited by its severe side effects. We have designed and synthesized a Gemini vitamin D analogue of calcitriol (UVB1) ...
Soluble yerba mate (Ilex Paraguariensis) extract enhances in vitro osteoblastic differentiation of bone marrow-derived mesenchymal stromal cells
(2019-11-15)
ETHNOPHARMACOLOGICAL RELEVANCE: Yerba mate (Ilex paraguariensis) consumption has been associated with beneficial effects on bone health. AIM OF THE STUDY: The purpose of this study was to evaluate the mechanism by which ...