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Estudo da imunogenicidade e segurança da vacina tríplice bacteriana acelular do adulto (dTpa) em crianças e adolescentes com artrite idiopática juvenil (AIJ)
(Universidade Federal de São Paulo (UNIFESP), 2017-05-25)
Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in childhood, accounting for varying degrees of physical disability. Protection of infections through active immunization is ...
Eventos adversos do tratamento medicamentoso de pacientes com doenças reumáticas autoimunes na infância: uma coorte retrospectiva em centro único
(Universidade Federal de São Paulo (UNIFESP), 2018-03-08)
Introduction: Autoimmune rheumatic diseases (AIRDs) are inflammatory diseases caused by changes in the immune system, and are manifested by joint involvement, as well as involvement of other organs and systems. Treatment ...
Caracterização do perfil de segurança infeccioso dos anticorpos monoclonais imunossupressores
(Universidade Federal de São Paulo (UNIFESP), 2021)
The occurrence of infections is a widely known adverse event for immunosuppressive drugs, including monoclonal antibodies (mAB). However, immunosuppressive therapy is not the only risk factor for the development of infections. ...
O brasil e o panorama regulatório de medicamentos biossimilares - comparação com europa, estados unidos, austrália e canadá
(Universidade Federal de São Paulo, 2022-12-19)
Introdução: A autorização e uso de medicamentos biossimilares é um tema de alta relevância nos últimos anos, desde a aprovação do primeiro biossimilar em 2006 na Europa. Desde então, as agências sanitárias mundiais vêm ...
TNF blockers show distinct patterns of immune response to the pandemic influenza A H1N1 vaccine in inflammatory arthritis patients
(OXFORD UNIV PRESSOXFORD, 2012)
Methods. One hundred and twenty patients (RA, n = 41; AS, n = 57; PsA, n = 22) on anti-TNF agents (monoclonal, n = 94; soluble receptor, n = 26) were compared with 116 inflammatory arthritis patients under DMARDs and 117 ...
Persistent Periodontal Disease Hampers Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2012-06)
Objective: This study aimed to evaluate prospectively the influence and the evolution of periodontal disease (PD) in rheumatoid arthritis (RA) patients submitted to anti-tumor necrosis factor (TNF) therapy. Methods: Eighteen ...
DESARROLLO Y ESTANDARIZACION DE TECNOLOGIAS PARA LA PRODUCCION DE ANTICUERPOS MONOCLONARES MODIFICADOS CON APLICACIONES EN BIOMEDICINA
(2009)
Las proteínas recombinantes terapéuticas, conocidas como biofármacos, han revolucionado la industria farmacéutica, esperándose una creciente demanda en los próximos años. Dentro de éstos, destacan los anticuerpos recombinantes ...
Detecção do DNA de Leishmania em pacientes com psoríase e/ ou artrite psoriásica em uso de imunossupressores
(2020-04-16)
Fundamentos: As drogas imunobiológicas revolucionaram o tratamento da psoríase e da artrite psoriásica, entretanto trouxeram o risco do desenvolvimento e reativação de doenças infecciosas, antes controladas pela resposta ...
Autoimmune diseases induced by biological agents. A review of 12,731 cases (BIOGEAS Registry)
(Informa Healthcare, 2017-11)
Introduction: Biological drugs are therapies designed to target a specific molecule of the immune system that have been linked with the development of autoimmune diseases. Areas covered: The BIOGEAS Registry currently ...
Influence on effectiveness of early treatment with anti-TNF therapy in rheumatoid arthritis
(Canadian Society for Pharmaceutical Sciences, 2012-05-16)
Purpose. To evaluate the association between starting early treatment with anti-TNF and effectiveness as well as the possibility of applying therapeutic spacing in daily practice in patients with rheumatoid arthritis (RA). ...