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Functional studies of the deubiquitinating enzymes USP19, USP4 and UCH-L1
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2013)
The conjugation of ubiquitin to proteins, known as ubiquitination, has different cellular functions; they include targeting proteins for degradation by the proteasome, regulation of DNA damage repair signaling, membrane ...
PPAR alpha Agonists Reduce Alcohol Drinking: Do They Act in the Brain or in the Liver?
(2015)
There are good news for the alcohol field. In the past few years, peroxisome proliferator-activator drugs were reported to reduce voluntary alcohol intake in animal models. Barson et al. (2009) showed that gemfibrozil ...
Speaker’s Oral presentationsPresentaciones orales del congreso
(Universidad Nacional de Córdoba, 2011)
Terapia Génica por Vectores Adenovirales en Modelos Animales de Alcoholismo: Inhibición de la Expresión del Gen de la Deshidrogenasa Aldehídica Mitocondrial Mediante un Gen Antisentido
(Universidad de Chile, 2006)
El alcoholismo es una enfermedad de etiología multifactorial que causa un número de
problemas sociales, laborales, legales y médicos. El riesgo de un individuo de
desarrollar alcoholismo está influenciado por varios ...
Sobre-expresión hepática de catalasa y su efecto en el consumo de alcohol en animales : desarrollo de vectores adenovirales codificantes de catalasa
(Universidad de Chile, 2019)
El alcohol es la droga más consumida en el mundo y su uso excesivo genera graves problemas. A pesar de la relevancia del alcoholismo, en la actualidad no existen herramientas farmacológicas efectivas para su tratamiento. ...
Parents ethanol use impairs ethanol-naive offspring development and reproduction
(2021-02-01)
Parental ethanol consumption can influence the offspring phenotype. In this way, we analyzed the impairments of maternal and paternal high ethanol consumption during postpuberty on the physical development, feeding pattern, ...
Gene therapy reduces ethanol intake in an animal model of alcohol dependence
(2008)
Background: Some gene polymorphisms strongly protect against the development of alcoholism. A large proportion of East Asians carry a protective inactivating mutation in aldehyde dehydrogenase (ALDH2*2). These subjects ...