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Mostrando ítems 11-20 de 47
Characterization And Screening Of Tight Binding Inhibitors Of Xanthine Oxidase: An On-flow Assay
(ROYAL SOC CHEMISTRYCAMBRIDGE, 2015)
Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial Complex i inhibition
(2011)
The aim of this work was to investigate the role of mitochondrial dysfunction in the development of oxidative stress and cytotoxicity induced by indomethacin and to evaluate the potential of an apple peel polyphenol extract ...
Identification of pyrazolotriazinones as potential agents for hyperuricemia treatment by using in vitro and in silico studies
(Springer Nature, 2020-07)
Heterocyclic compounds structurally related to purine bases have been described as anticonvulsants, antifungal, antiviral, anticancer, enzyme inhibitors, among others. In this work, pyrazolo[3,4-d][1-3]triazin-4-ones (2) ...
Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer
(Elsevier Ireland, 2001-03)
Epidemiological evidence links alcohol intake with increased risk in breast cancer. Not all the characteristics of the correlation can be explained in terms of changes in hormonal factors. In this work, we explore the ...
Pyrogallol red oxidation induced by superoxide radicals: Application to evaluate redox cycling of nitro compounds
(2011)
The bleaching of the pyrogallol red (PGR) dye mediated by superoxide anion radicals (O2-) generated from the xanthine/xanthine oxidase system (X/XO) was studied by UV-visible spectrophotometry. The absorption band (at 540 ...
Determinación espectrofotométrica de la actividad inhibitoria de xantina oxidasa en extractos de algunas plantas melastomataceas
(Pereira : Universidad Tecnológica de PereiraFacultad de Ciencias Básicas, 2011)
Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy
(2014)
Hypoxia is a common challenge to the fetus, promoting a physiological defence to redistribute blood flow towards the brain and away from peripheral circulations. During acute hypoxia, reactive oxygen species (ROS) interact ...
Kinetic and structural studies of aldehyde oxidoreductase from Desulfovibrio gigas reveal a dithiolene-based chemistry for enzyme activation and inhibition by H2O2
(Public Library of Science, 2013-12-31)
Mononuclear Mo-containing enzymes of the xanthine oxidase (XO) family catalyze the oxidative hydroxylation of aldehydes and heterocyclic compounds. The molybdenum active site shows a distorted square-pyramidal geometry in ...
Xanthine Oxidase Activation Modulates the Endothelial (Vascular) Dysfunction Related to HgCl2 Exposure Plus Myocardial Infarction in Rats
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAUFMG, 2017)
A exposição a metais pesados está associada a doenças cardiovasculares, como infarto do miocárdio (IM). A disfunção vascular está relacionada tanto às causas quanto às consequências do IM. Investigamos se a exposição ...
Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity
(Oxford University Press, 2014-01)
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that ...