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Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning
(2012)
L-3,3′,5-triiodothyronine (T3) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection. In this work, we studied the role ...
Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders
Systems medicine is founded on a mechanism-based approach and identifies in this way
specific therapeutic targets. This approach has been applied for the transcription factor nuclear
factor (erythroid-derived 2)–like 2 ...
Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2
(PERGAMON-ELSEVIER SCIENCE LTD, 2006)
The properties of bucillamine, a synthetic antioxidant, have been attributed mainly to the donation of thiol groups to glutathione (GSH). We recently demonstrated that glutamatecysteine ligase catalytic subunit (GCLC), the ...
Hepatic Nrf2 expression is altered by quercetin supplementation in X.irradiated rats
(Spandidos Publications, 2015)
Oxidative stress produced by hyperthyroidism status induces the antioxidant enzyme transcription through the activation of the nrf-2 factor in lymphoid tissues of balb/c mice
(Hindawi, 2019)
Abstract: Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid hormones T3 and T4. Thyroid hormones exert pleiotropic actions on numerous tissues and induce an overall increase in ...
Efecto del estrés crónico emocional sobre la regulación de la expresión y actividad de NRF2 en el hipocampo ventral de ratas macho y hembra
(Universidad de Chile, 2022)
Los estudios epidemiológicos han demostrado que las mujeres tienen una mayor incidencia de trastornos del estado de ánimo, como ansiedad y depresión mayor, que los hombres. Ambos trastornos están asociados con el estrés, ...
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
(Elsevier B.V., 2018)
© 2018 Elsevier Inc. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include ...
Testosterone induces up-regulation of mitochondrial gene expression in murine C2C12 skeletal muscle cells accompanied by an increase of nuclear respiratory factor-1 and its downstream effectors
(Elsevier Ireland, 2020-01-15)
The reduction in muscle mass and strength with age, sarcopenia, is a prevalent condition among the elderly, linked to skeletal muscle dysfunction and cell apoptosis. We demonstrated that testosterone protects against ...