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Efeitos pré e pós sinápticos dos inibidores da acetilcolinesterase na neurotransmissão em musculatura lisa.
(Universidade Federal de São Paulo (UNIFESP), 2010-11-24)
Justification: The present work considers the effects of new inhibitors of acetylcholinesterase (AChE) on the reactivity and neurotransmission in rats and mice. The new anticholinesterase compounds, ITH12118 and ITH12117, ...
Anticholinesterasic, Nematostatic and Anthelmintic Activities of Pyridinic and Pyrazinic Compounds
(Bentham Science Publ Ltd, 2011-08-01)
In the search for acetylcholinesterase inhibitors as a potential target for the discovery of anthelmintic drugs, a series of 27 pyridinic and pyrazinic compounds have been designed on the basis of molecular hybridization ...
Anticholinesterasic, Nematostatic and Anthelmintic Activities of Pyridinic and Pyrazinic Compounds
(Bentham Science Publ Ltd, 2011-08-01)
In the search for acetylcholinesterase inhibitors as a potential target for the discovery of anthelmintic drugs, a series of 27 pyridinic and pyrazinic compounds have been designed on the basis of molecular hybridization ...
The implementation of NMR techniques for measuring interactions between small organic molecules/inhibitors and enzyme Acetylcholinesterase: a step towards Alzheimer´s control
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2015-05-21)
The inhibition of the acetylcholinesterase (AChE) might be an excellent therapy in controlling Alzheimer’s disease as stated by the cholinergic hypothesis. In this context, the inhibitors of AChE, are of medical and ...
Estudos bioquímicos e cinéticos de acetilcolinesterases de formigas cortadeiras (Atta sexdens)
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2017-09-29)
Acetylcholinesterase (AChE) (EC 3.1.1.7) is the enzyme responsible for catalyzing the hydrolysis of the neurotransmitter acetylcholine leading to the release of acetate and choline. In insects, acetylcholine is one of the ...
Anticholinesterasic, Nematostatic and Anthelmintic Activities of Pyridinic and Pyrazinic Compounds
(Bentham Science Publ Ltd, 2014)
Estudos computacionais e sintéticos visando o planejamento racional de novos agentes anticolinesterásicos
(Universidade Estadual Paulista (Unesp), 2010-08-13)
O presente trabalho teve como objetivo o planejamento e síntese de novas substâncias inibidoras da acetilcolinesterase, enzima cuja modulação está associada ao tratamento de diversas patologias, entre elas a doença de ...
Estudos computacionais e sintéticos visando o planejamento racional de novos agentes anticolinesterásicos
(Universidade Estadual Paulista (UNESP), 2014)
Modelo preditivo qsar para avaliação da atividade de inibidores de acetilcolinesterasePredictive qsar model for assessing activity of acetyl cholinesterase inhibitors
(Universidade Federal da Grande DouradosBrasilFaculdade de Ciências Biológicas e AmbientaisUFGD, 2022)