Buscar
Mostrando ítems 11-20 de 199
Novel sodium/Iodide symporter compound heterozygous pathogenic variants causing dyshormonogenic congenital hypothyroidism
(Mary Ann Liebert, 2019-07)
Iodide transport defect (ITD) is an autosomal recessive disorder caused by deficient iodide accumulation into the thyroid follicular cell. ITD is an uncommon cause of dyshormonogenetic congenital hypothyroidism that results ...
The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane
(Federation of American Societies for Experimental Biology, 2021-07)
The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis. Loss-of-function NIS variants cause ...
New insights about the posttranscriptional mechanisms triggered by iodide excess on sodium/iodide symporter (NIS) expression in PCCl3 cells
(ELSEVIER IRELAND LTDCLARE, 2012)
Iodide excess acutely downregulates NIS mRNA expression, as already demonstrated. PCCl3 cells treated or not with Nal, Nal + NaClO4 or Nal + Methimazole, for 30 min to 24 h, were used to further explore how iodide reduces ...
The Acute Inhibitory Effect of Iodide Excess on Sodium/Iodide Symporter Expression and Activity Involves the PI3K/Akt Signaling Pathway
(Endocrine Society, 2014-03)
Iodide (I−) is an irreplaceable constituent of thyroid hormones and an important regulator of thyroid function, because high concentrations of I− down-regulate sodium/iodide symporter (NIS) expression and function. In ...