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The synthetic Varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins
(2021)
The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory and local ...
Characterization of small-molecule inhibitors of the sodium iodide symporter
The sodium/iodide symporter (NIS) mediates the active transport of iodide from the bloodstream into thyrocytes. NIS function is strategic for the diagnosis and treatment of various thyroid diseases. In addition, a promising ...
Investigating molecular dynamics-guided lead optimization of EGFR inhibitors
(Pergamon-Elsevier Science Ltd, 2016-02-15)
The epidermal growth factor receptor (EGFR) is part of an extended family of proteins that together control aspects of cell growth and development, and thus a validated target for drug discovery. We explore in this work ...
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth
(Elsevier Ireland, 2020-02)
Despite prophylactic vaccination campaigns, human papillomavirus (HPV)-induced cancers still represent a major medical issue for global population, thus specific anti-HPV drugs are needed. Since the ability of HPV E6 ...
Targeted Therapies For The Treatment Of Non-small-cell Lung Cancer: Monoclonal Antibodies And Biological Inhibitors
(Taylor & Francis IncPhiladelphia, 2017)
Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules
(American Chemical Society, 2015-08)
Methicillin-resistant Staphylococcus aureus (MRSA), an important human pathogen, has evolved an inducible mechanism for resistance to β-lactam antibiotics. We report herein that the integral membrane protein BlaR1, the β- ...
Discovery Of Small Molecule Inhibitors For The Snake Venom Metalloprotease Bap1 Using In Silico And In Vitro Tests
(Pergamon-Elsevier Science LTDOxford, 2017)