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A new approach for pyrazinamide susceptibility testing in mycobacterium tuberculosis
(Mary Ann Liebert, 2012)
Background: Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis. Microbiological methods of PZA susceptibility testing are controversial and have low reproducibility. After conversion of PZA into ...
The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats
(Wiley-Blackwell, 2007-09-01)
Hepatotoxicity is the main concern during tuberculosis chemotherapy with the first-line drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR). Since these hepatotoxic events have been associated with INH metabolites, ...
The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats
(Wiley-Blackwell, 2007-09-01)
Hepatotoxicity is the main concern during tuberculosis chemotherapy with the first-line drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR). Since these hepatotoxic events have been associated with INH metabolites, ...
A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
(Medknow Publications, 2018)
Introduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these ...
Direct determination of pyrazinamide (PZA) susceptibility by sputum microscopic observation drug susceptibility (MODS) culture at neutral pH: the MODS-PZA assay
(American Society for Microbiology, 2020)
Pyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is ...
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
(Wiley-Blackwell, 2014)
The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats
(Wiley-Blackwell, 2014)
pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of Brazil
(Oxford University Press, 2006-11-01)
Objectives: To investigate the presence of mutations in the pncA gene in 31 pyrazinamide-resistant Mycobacterium tuberculosis and 5 susceptible strains. MICs and pyrazinamidase (PZase) activity were also determined.Methods: ...
pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of Brazil
(Oxford University Press, 2006-11-01)
Objectives: To investigate the presence of mutations in the pncA gene in 31 pyrazinamide-resistant Mycobacterium tuberculosis and 5 susceptible strains. MICs and pyrazinamidase (PZase) activity were also determined.Methods: ...
The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats
(Wiley-Blackwell, 2014)