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Alterations in PTEN, MDM2, TP53 and AR protein and gene expression are associated with canine prostate carcinogenesis
(2016-06-01)
The PTEN, AR, MDM2 and p53 protein network plays a central role in the development of many human cancers, thus eliciting the development of targeted cancer therapeutics. Dogs spontaneously develop tumours, and they are ...
A single synonymous mutation determines the phosphorylation and stability of the nascent protein
(Oxford University Press, 2019)
p53 is an intrinsically disordered protein with a large number of post-translational modifications and interacting partners. The hierarchical order and subcellular location of these events are still poorly understood. The ...
p53, Mdm2, and c-Myc overexpression is associated with a poor prognosis in aggressive non-Hodgkin's lymphomas
(Wiley-lissNew YorkEUA, 2001)
Molecular and iochemical techniques for deciphering p53-MDM2 regulatory mechanisms
(MDPI, 2021)
The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of interactions with multiple partners and functions. Intrinsically disordered regions help to adopt function-specific structural conformations ...