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Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis
(John Wiley & Sons Inc, 2010-10-29)
LKB1, originally considered a tumor suppressor, plays an important role in hepatocyte proliferation and liver regeneration. Mice lacking the methionine adenosyltransferase (MAT) gene MAT1A exhibit a chronic reduction in ...
Inhibition of AMPK and Krebs Cycle Gene expression drives metabolic remodeling of Pten-Deficient Preneoplastic thyroid cells
(American Association for Cancer Research, 2013-09)
Rapidly proliferating and neoplastically transformed cells generate the energy required to support rapid cell division by increasing glycolysis and decreasing flux through the oxidative phosphorylation (OXPHOS) pathway, ...
Ceratocystis cacaofunesta genome analysis reveals a large expansion of extracellular phosphatidylinositol-specific phospholipase-C genes (PI-PLC)
(BioMed Central Ltd., 2018-01-17)
Background: The Ceratocystis genus harbors a large number of phytopathogenic fungi that cause xylem parenchyma degradation and vascular destruction on a broad range of economically important plants. Ceratocystis cacaofunesta ...
Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase
(2013)
Yunis-Varón syndrome (YVS) is an autosomal-recessive disorder with cleidocranial dysplasia, digital anomalies, and severe neurological involvement. Enlarged vacuoles are found in neurons, muscle, and cartilage. By whole-exome ...
On-site single pollen metabolomics reveals varietal differences in phosphatidylinositol synthesis under heat stress conditions in rice
(Nature, 2020-12)
Although a loss of healthy pollen grains induced by metabolic heat responses has been indicated to be a major cause of heat-induced spikelet sterility under global climate change, to date detailed information at pollen ...
A Tomato Tocopherol-Binding Protein Sheds Light on Intracellular α-Tocopherol Metabolism in Plants
(NLM (Medline), 2018)
Tocopherols are non-polar compounds synthesized in the plastids, which function as major antioxidants of the plant cells and are essential in the human diet. Both the intermediates and final products of the tocopherol ...
Evidence for a direct effect of captopril on early steps of insulin action in BC3H-1 myocytes
(W B Saunders CoPhiladelphiaEUA, 2003)
Functional muscarinic receptors in cultured skeletal muscle
(Academic Press Inc., 1996)
We studied the influence of muscarinic and nicotinic stimulation on both phosphoinositide metabolism and intracellular calcium levels in rat skeletal muscle primary cultures. Both nicotine and muscarine induced an increase ...
A tomato tocopherol binding protein sheds light on intracellular α-tocopherol metabolism in plants
(NLM (Medline), 2018-11)
Tocopherols are non-polar compounds synthesized in the plastids, which function as major antioxidants of the plant cells and are essential in the human diet. Both the intermediates and final products of the tocopherol ...
A Tomato Tocopherol-Binding Protein Sheds Light on Intracellular alpha-Tocopherol Metabolism in Plants
(OXFORD UNIV PRESS, 2018)
Tocopherols are non-polar compounds synthesized in the plastids, which function as major antioxidants of the plant cells and are essential in the human diet. Both the intermediates and final products of the tocopherol ...