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Mostrando ítems 11-20 de 173
Efeito neurodegenerativos causados pela deficiência de vitamina B1
(Universidade Federal de Minas GeraisUFMG, 2006-08-11)
Oxidative stress, selective neuronal loss, and diminished activity of thiaminedependent enzymes is assumed to characterize most of the neurodegenerative diseases. Thiamine deficiency (TD) models have been used to produce ...
Electrical Oscillations in Two-Dimensional Microtubular Structures
(Nature Publishing Group, 2016-06)
Microtubules (MTs) are unique components of the cytoskeleton formed by hollow cylindrical structures of αβ tubulin dimeric units. The structural wall of the MT is interspersed by nanopores formed by the lateral arrangement ...
Biophysical characterization of the role of synthesized toxins from Pamphobeteus verdolaga spider on voltage-gated calcium and potassium channels by the electrophysiological patch-clamp technique
(Grupo de Investigación en Fisiología y Bioquímica - PhysisMedellín - Colombia, 2022)
Nitric oxide modulates the firing rate of the rat supraoptic magnocellular neurons
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
In vitro, nitric oxide (NO) inhibits the firing rate of magnocellular neurosecretory cells (MNCs) of hypothalamic supraoptic and paraventricular nuclei and this effect has been attributed to GABAergic activation. However, ...
Characterization of selectivity and pharmacophores of type 1 sea anemone toxins by screening seven Na-v sodium channel isoforms
(ELSEVIER SCIENCE INCNEW YORK, 2013-08-02)
During their evolution, animals have developed a set of cysteine-rich peptides capable of binding various extracellular sites of voltage-gated sodium channels (VGSC). Sea anemone toxins that target VGSCs delay their ...
Decreased excitability of locus coeruleus neurons during hypercapnia is exaggerated in the streptozotocin-model of Alzheimer's disease
(2020-06-01)
The locus coeruleus (LC) is a pontine nucleus important for respiratory control and central chemoreception. It is affected in Alzheimer's disease (AD) and alteration of LC cell function may account for respiratory problems ...
4-Chloro-3-nitro-N-butylbenzenesulfonamide acts on KV3.1 channels by an open-channel blocker mechanism
(2017-11-01)
The effects of 4-chloro-3-nitro-N-butylbenzenesulfonamide (SMD2) on KV3.1 channels, heterologous expressed in L-929 cells, were studied with the whole cell patch-clamp technique. SMD2 blocks KV3.1 in a reversible and ...
Altered voltage dependent calcium currents in a neuronal cell line derived from the cerebral cortex of a trisomy 16 fetal mouse, an animal model of down syndrome
(2012)
Human Down syndrome (DS) is determined by the trisomy of autosome 21 and is expressed by multiple abnormalities, being mental retardation the most striking feature. The condition results in altered electrical membrane ...