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N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin
(2016)
Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid
beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here
we report, the discovery ...
N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin
(2016)
Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid
beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here
we report, the discovery ...
c-Abl modulates AICD dependent cellular responses: Transcriptional induction and apoptosis
(2009)
APP intracellular domain (AICD) has been proposed as a transcriptional inductor that moves to the nucleus with the adaptor protein Fe65 and regulates transcription. The two proteins, APP and Fe65, can be phosphorylated by ...
Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases
(2018)
Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through ...
c-Abl modulates AICD dependent cellular responses: Transcriptional induction and apoptosis
(2009)
APP intracellular domain (AICD) has been proposed as a transcriptional inductor that moves to the nucleus with the adaptor protein Fe65 and regulates transcription. The two proteins, APP and Fe65, can be phosphorylated by ...
Frontotemporal dementia and potential therapeutics.
(Nova Science Publishers, 2017)
Memory impairment due to aging and various memory disorders represent a great medical challenge to our society. Since the publication of the fifth volume of this collection, the rapid progress in the research fields of ...
Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates
(Portland Press Ltd, 2005-01-15)
APP (aminopeptidase P) has the unique ability to cleave the N-terminal amino acid residue from peptides exhibiting a proline at P-1'. Despite its putative involvement in the processing of bioactive peptides, among them the ...