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Molecular biology of the kallikrein-kinin system: from structure to function
(Associação Brasileira de Divulgação Científica, 1998-09-01)
The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and ...
SUBSTRATE SPECIFICITIES of TISSUE KALLIKREIN and T-KININOGENASE - THEIR POSSIBLE ROLE in KININOGEN PROCESSING
(Amer Chemical Soc, 1992-06-02)
The present studies demonstrate the importance of subsite interactions in determining the cleavage specificities of kallikrein gene family proteinases. the effect of substrate amino acid residues in positions P3-P'3 on the ...
Pharmacological characterization of novel tissue kallikrein inhibitors in vivo
(Elsevier B.V., 1996-05-01)
In this study we have investigated the effect of novel tissue kallikreins on the plasma protein exudation induced by porcine pancreatic kallikrein (PPK) in the rabbit skin in vivo. the tissue kallikrein inhibitors here ...
Kallikrein-kinin system in hepatic experimental models
(Elsevier B.V., 2005-08-01)
The purpose of this brief review is to describe some characteristics of the kallikrein-kinin system (KKS) in the liver. the liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in ...
The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models
(Elsevier B.V., 2014-05-01)
The Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity ...
VARIATIONS IN UTERINE KALLIKREIN DURING CYCLE AND EARLY-PREGNANCY IN THE RAT
(OXFORD UNIV PRESS INC, 1994)
We have previously demonstrated the presence of tissue kallikrein and its mRNA in rat uterus, and an increase of the immunoreactive enzyme on Day 7 of gestation, which suggests a hormonal regulation and a role in implantation. ...
Design of inhibitors for human tissue kallikrein using non-natural aromatic and basic amino acids
(Walter de Gruyter & Co, 2002-05-01)
We explored the unique substrate specificity of the primary S1 subsite of human urinary kallikrein (hK1), which accepts both Phe or Arg synthesizing and assaying peptides derived from PhenylacetylPheSer ArgEDDnp, a previously ...