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Calcium mediates the NO-induced potassium current in toad and rat olfactory receptor neurons
(2000)
Nitric oxide (NO) activates a K+ current in dissociated amphibian olfactory receptor neurons. Using the patch-clamp technique in its whole-cell mode and stimulation with puffs of the NO-donor sodium nitroprusside, we further ...
Determination of the stoichiometry between alpha- and gamma 1 subunits of the BK channel using LRET
(Cell Press, 2018)
Two families of accessory proteins, beta and gamma, modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the gamma 1 subunit promotes a large shift of the BK conductance-voltage curve to ...
Ca2+-dependent K+ channels from rat olfactory cilia characterized in planar lipid bilayers
(ELSEVIER SCIENCE BV, 2005-03-14)
Olfactory cilia contain cyclic nucleotide-gated and Ca2+-dependent Cl- conductances that underlie excitatory chemotransduction, and a Ca2+-dependent K+ (K-Ca) conductance, apparently involved in inhibitory transduction. ...
Cyclic AMP cascade mediates the inhibitory odor response of isolated toad olfactory receptor neurons
(AMER PHYSIOLOGICAL, 2005-09)
Odor stimulation may excite or inhibit olfactory receptor neurons (ORNs). It is well established that the excitatory response involves a cyclic AMP (cAMP) transduction mechanism that activates a nonselective cationic cyclic ...
Signaling path of the action of AVP on distal K+ secretion
(Blackwell Publishing, 2014)
Impaired beta-adrenoceptor-induced relaxation in small mesenteric arteries from DOCA-salt hypertensive rats is due to reduced K-Ca channel activity
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDLONDON, 2012)
beta-Adrenoceptor (beta-AR)-mediated relaxation plays an important role in the regulation of vascular tone. beta-AR-mediated vascular relaxation is reduced in various disease states and aging. We hypothesized that ...
Role of membrane potential and expression of endothelial factors in Restenosis after angioplasty in SHR
(Lippincott Williams & Wilkins, 2004-01-01)
We examined the roles played by impaired K+ channels, diminished nitric oxide (NO) production, endothelin release, and smooth muscle membrane potential in the increased restenosis observed in spontaneously hypertensive rat ...
Alpha-2 adrenoceptors are present in rat aorta smooth muscle cells, and their action is mediated by ATP-sensitive K+ channels
(Nature Publishing Group, 2000-10-01)
1 the role of alpha (2)-adrenoceptors in the response of aorta smooth muscle rings to the alpha (2)- adrenoceptors agonists UK 14,304 and clonidine was studied.2 Stimulation by 1-10 nM UK 14,304 caused dose-dependent ...
Protein kinase C modulators enhance angiotensin II desensitization of guinea pig ileum via maxi-K+ channels
(Elsevier B.V., 2002-05-03)
We investigated the role of protein kinase in the desensitization of the angiotensin II induced contraction of guinea pig ileum. in contrast to their antagonistic effects on enzymatic activity, body activation blockers ...
Effect of uroguanylin on potassium and bicarbonate transport in rat renal tubules
(Natl Research Council Canada-n R C Research Press, 2006-10-01)
The effect of uroguanylin (UGN) oil K(+) and H(+) secretion in the renal tubules of the rat kidney was studied using in vivo stationary microperfusion. For the study of K(+) secretion, a tubule was Punctured to inject a ...