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Wnt - 7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons
(2008)
Wnt signaling is essential for neuronal development and the maintenance of the developing nervous system. Recent studies indicated that Wnt signaling modulates long term potentiation in adult hippocampal slices. We report ...
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
(NATL ACAD SCIENCES, 2010)
Growing evidence indicates that Wingless-type (Wnt) signaling plays an important role in the maturation of the central nervous system. We report here that Wingless-type family member 5A (Wnt-5a) is expressed early in ...
Production of nerve growth factor by β-amyloid-stimulated astrocytes induces p75NTR-dependent tau hyperphosphorylation in cultured hippocampal neurons
(2006)
Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that β-amyloid peptide induces inflammatory-like responses in astrocytes, leading to ...
Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons
(2004)
Production of nitric oxide (NO) by glial cells has been proposed to mediate cytotoxic effects on neighboring neurons. Although extensive genetic data implicate the beta amyloid peptide (Aβ) in the neurodegenerative cascade ...
Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro
(Elsevier Inc, 2011-07)
After approximately 3 weeks in vitro, hippocampal neurons present many of the typical hallmarks accompanying neuronal aging in vivo, including accumulation of reactive oxygen species (ROS), lipofuscin granules, heterochromatic ...
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
(2007)
Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox modification ...
Sex-related long-term behavioral and hippocampal cellular alterations after nociceptive stimulation throughout postnatal development in rats
(ElsevierAmsterdam, 2014-02)
Early noxious stimuli may alter the neurogenesis rate in the dentate gyrus and the behavioral repertoire of adult rats. This study evaluated the long-term effects of noxious stimulation, imposed in different phases of ...
The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
(Pergamon-Elsevier Science Ltd, 2015-01)
An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic ...
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitocondrial fission and stimulates mitocondrial Ca2+ uptake inprimary hippocampal neurons
(2014)
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...