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Dissecting the functional roles of the conserved NXXE and HXE motifs of the ADP-dependent glucokinase from Thermococcus litoralis
(Elsevier, 2015)
The activity of the ADP-dependent glucokinase from Thermococcus litoralis (TlGK) relies on the
highly conserved motifs NXXE (i.e. Asn-Xaa-Xaa-Glu) and HXE (i.e. His-Xaa-Glu). Site-directed mutagenesis
of residues Glu279 ...
Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior.
(2017)
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic beta-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). ...
Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes.
(2014)
Glucokinase (GK), the hexokinase involved in glucose sensing in pancreatic beta cells, is also expressed in hypothalamic tanycytes, which cover the ventricular walls of the basal hypothalamus and are implicated in an ...
Role of Islet Glucokinase, Glucose Metabolism, and Insulin Pathway in the Enhancing Effect of Islet Neogenesis-Associated Protein on Glucose-Induced Insulin Secretion
(Lippincott Williams, 2015-08)
Objective: To demonstrate the role of islet glucokinase, glucose metabolism, and intracellular insulin mediators in the enhancing effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) on glucoseinduced ...
Bifunctional ADP-dependent phosphofructokinase/glucokinase activity in the order methanococcales - biochemical characterization of the mesophilic enzyme from methanococcus maripaludis
(Blackwell Publishing Ltd, 2014)
In some archaea, the phosphorylation of glucose and fructose 6-phosphate (fructose 6P) is carried out by enzymes that are specific for either substrate and that use ADP as phosphoryl donor. In the hyperthermophilic archaeon ...
Maintenance of the monomeric structure of glucokinase under reacting conditions
(1978)
Glucokinase is a monomeric protein under native and denaturating conditions yet presents a sigmoidal saturation function for glucose. These peculiarities suggested the possibility that polymerization occurs under assay ...
Induction of glucokinase by glucose in rat liver
(1963)
EVIDENCE that the nature and amount of carbohydrates in the diet significantly influence the activity of several enzymes related to carbohydrate metabolism is now accumulating. Among other enzymes, glucokinase decreases ...
MODY 2: Mutation identification and molecular ancestry in a Brazilian family
(2013-01-10)
Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of genetic diseases characterized by a primary defect in insulin secretion and hyperglycemia, non-ketotic disease, monogenic autosomal dominant mode of ...
MODY 2: Mutation identification and molecular ancestry in a Brazilian family
(2013-01-10)
Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of genetic diseases characterized by a primary defect in insulin secretion and hyperglycemia, non-ketotic disease, monogenic autosomal dominant mode of ...