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Glucocorticoid receptor β overexpression has agonist-independent insulin-mimetic effects on HepG2 glucose metabolism
(MDPI, 2022)
Glucocorticoids (GC) are steroids hormones that drive circulating glucose availability through gluconeogenesis in the liver. However, alternative splicing of the GR mRNA produces two isoforms, termed GR alpha and GR beta. ...
The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51
(Nature Publishing Group, 2016-10)
FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids. However, the understanding of the molecular ...
Glucocorticoid receptor in the rat epididymis: Expression, cellular distribution and regulation by steroid hormones
(Elsevier B.V., 2010-08-30)
Glucocorticoids regulate several physiological functions, including reproduction, in mammals. Curiously, little is known about glucocorticoid-induced effects on the epididymis, an androgen-dependent tissue with vital role ...
Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor
(BioMed Central, 2020-06)
Background: Functional compartmentalization has emerged as an important factor modulating the kinetics and specificity of biochemical reactions in the nucleus, including those involved in transcriptional regulation. The ...
Structural Insights into the Ligand Binding Domain of the Glucocorticoid Receptor: A Molecular Dynamics Study
(American Chemical Society, 2019-11)
The glucocorticoid receptor (GR) is a ligand-binding dependent transcription factor that ultimately regulates vital biological processes and inflammation response through specific gene expression control, thus representing ...
The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells
(Oxford University Press, 2019-10)
The glucocorticoid and progesterone receptors (GR and PR) are closely related members of the steroid receptor family. Despite sharing similar structural and functional characteristics; the cognate hormones display very ...
Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice
(MDPI, 2020)
Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid ...
The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction
(Federation of American Societies for Experimental Biology, 2007-04)
Glucocorticoids (GCs) immunosuppression acts via regulation of several transcription factors (TF), including AP-1, NFkB and NFAT. GCs inhibit Th1 cytokines and promote a shift towards Th2 differentiation. Th1 phenotype ...
Increased expression of the glucocorticoid receptor β in infants with RSV bronchiolitis
(2012)
OBJECTIVES: The majority of studies on glucocorticoid treatment in respiratory syncytial virus (RSV) bronchiolitis concluded that there are no beneficial effects. We hypothesized that RSV-infected patients may have an ...