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Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin
(Taylor and Francis, 2016)
From its introduction in 1952 onwards, the clinical use of macrolides has been steadily increasing, both in human and veterinary medicine. Although initially designed to the treatment of Gram-positive microorganisms, this ...
Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia
(Oxford University Press, 2015)
Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with ...
Entinostat (SNDX-275) for the treatment of non-small cell lung cancer
(Taylor and Francis, 2015)
INTRODUCTION: Epigenetic aberrations play an important role in lung carcinogenesis. Chromatin deacetylation is a fundamental mechanism of gene silencing. Histone deacetylase (HDAC) inhibitors are an emerging class of ...
Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure
(American Society for Microbiology, 2016)
The Xpert MTB/RIF assay is both sensitive and specific as a diagnostic test. Xpert also reports quantitative output in cycle threshold (CT) values, which may provide a dynamic measure of sputum bacillary burden when used ...
Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms
(BioMed Central, 2017)
BACKGROUND: Treatment with erythropoietin (Epo) in experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple sclerosis (MS), has consistently been shown to ameliorate disease progression and improve ...
Myeloproliferative neoplasms with t(8;22)(p11.2;q11.2)/BCR-FGFR1: a meta-analysis of 20 cases shows cytogenetic progression with B-lymphoid blast phase
(Elsevier, 2017)
Rearrangements of FGFR1 result in the 8p11 myeloproliferative syndrome, a group of rare diseases that features a myeloproliferative neoplasm (MPN) that commonly progresses to lymphoblastic leukemia/lymphoma or acute myeloid ...
GSTT1, GSTM1, and GSTP1 polymorphisms as a prognostic factor in women with breast cancer
(Funpec-editoraRibeirao PretoBrasil, 2014)
Impact of genetic polymorphism of metabolic pathway of methotrexate and survival rate of Mexican children will all [Impacto de polimorfismos genéticos de la vía metabólica del metotrexato sobre la sobrevida de niños Mexicanos con leucemia linfoblástica aguda (LLA)]
(UNIVERSIDAD DE ANTIOQUIA, 2015-01-01)
Background: Acute lymphoblastic leukemia (ALL) is a major cancer disease in Mexican pediatric population, were the genotype could affect the effectiveness of chemotherapy in which the methotrexate (MTX) is involved and ...