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Synthesis, 5-hydroxytryptamine1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives
(Pharmaceutical Society of Japan, 2012)
Identification of a New Hormone-Binding Site on the Surface of Thyroid Hormone Receptor
(Endocrine SocWashingtonEUA, 2014)
Amphetamine derivatives as monoamine oxidase inhibitors
(Frontiers Media S.A., 2020)
GABAA Receptor Binding and Ion Channel Function in Primary Neuronal Cultures for Neuropharmacology/Neurotoxicity Testing
(Humana Press, 2011)
GABAA receptor (GABAAR) constitutes the main inhibitory receptor of the central nervous system. Due to the wide distribution and activity of its main neurotransmitter agonist, the γ-aminobutyric acid (GABA), its pharmacology ...
Flunitrazepam–Membrane Binding: A Sensor for Drug-Induced GABAA-R and Membrane Structure Changes
(Elsevier Academic Press Inc., 2016)
Flunitrazepam (FNZ) is a sedative–hypnotic benzodiazepine with important therapeutic usefulness and significant abuse liability. Its capability to induce anterograde amnesia favors FNZ use as a “date-rape drug” administered ...
Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects
(Bentham Science Publishers, 2017-09)
ABC transporters are membrane proteins mediating the efflux of endo- and xenobiotics. Transporter expression is not static but instead is subject to a dynamic modulation aiming at responding to changes in the internal ...
Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists
(Public Library of Science, 2011)
CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis ...