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Mostrando ítems 11-20 de 500
Characterization of thiol-, aspartyl-, and thiol-metallo-peptidase activities in Madin-Darby canine kidney cells
(Wiley-Blackwell, 2000-01-01)
We combined fluorogenic substrates or internally quenched fluorescent peptides with specific inhibitors in the pH profile of proleolytic activity experiments in order to detect proteolytic activities in lysates of MDCK ...
Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
A new series of organotelluranes were synthesized and investigated, and the structure-activity relationships in cysteine proteases inhibition were determinated. It was possible to identify the relevance of structural ...
Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S
(Elsevier B.V., 2011-03-15)
A new series of organotelluranes were synthesized and investigated, and the structure-activity relationships in cysteine proteases inhibition were determinated. It was possible to identify the relevance of structural ...
Corneal angiogenesis modulation by cysteine cathepsins: in vitro and in vivo studies
(Elsevier B.V., 2015-05-01)
Corneal avascularization is essential for normal vision. Several antiangiogenic factors were identified in cornea such as endostatin and angiostatin. Cathepsin V, which is highly expressed in the cornea, can hydrolyze human ...
A possible alternative mechanism of kinin generation in vivo by cathepsin L
(Walter de Gruyter & Co, 2005-07-01)
We investigated the ability of cathepsin L to induce a hypotensive effect after intravenous injection in rats and correlated this decrease in blood pressure with kinin generation. Simultaneously with blood pressure decrease, ...
Transient expression of progesterone receptor and cathepsin-l in human granulosa cells during the periovulatory period
(Elsevier, 2012-03)
Objective: To study in vivo the progesterone receptor (PR) expression levels in human granulosa cells (GCs) during the periovulatory period and the
affect of the protein kinase A (PKA) pathway on PR expression and cathepsin-L ...
Purification and partial characterization of cathepsin D from porcine (Sus scrofa) liver using affinity chromatography
(Academic Press Aust, 1998-07-01)
Cathepsin D, a lysosomal aspartic protease, has been purified from porcine liver using a combination of pepstatin-A agarose and Affi-Gel Blue affinity chromatography, followed by size-exclusion chromatography. The purified ...
Chlorhexidine Inhibits the Activity of Dental Cysteine Cathepsins
(Sage Publications IncThousand OaksEUA, 2012)