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Sonic hedgehog in cancer stem cells: A novel link with autophagy
(2012)
The Sonic Hegdehog/GLI (SHH/GLI) pathway has been extensively studied for its role in developmental and cancer biology. During early embryonic development the SHH pathway is involved mainly in pattern formation, while in ...
Evaluation of melatonin effect on human breast cancer stem cells using a threedimensional growth method of mammospheres
(2017-01-01)
Background: The high rates of women's death from breast cancer occur due to acquired resistance by patients to certain treatments, enabling the recurrence and/or tumor growth, invasion and metastasis. It has been demonstrated ...
Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture
(Wiley-liss, Div John Wiley & Sons Inc, 2018-02)
Breast cancer human cells culture as spheroids develop autophagy and apoptosis, which promotes Trastuzumab resistance in HER2 overexpressing cells. Our aim was to study the association of the hostile environment developed ...
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy
(BioMed Central, 2015)
Abstract
Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release ...
Understanding the influence of substrate when growing tumorspheres
(BioMed Central, 2021-12)
Background: Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell ...
Connexin46 Expression Enhances Cancer Stem Cell and Epithelial-to-Mesenchymal Transition Characteristics of Human Breast Cancer MCF-7 Cells
(2021)
Connexins (Cxs) are a family of proteins that form two different types of ion channels: hemichannels and gap junction channels. These channels participate in cellular communication, enabling them to share information and ...
The germline markers NANOS and DDX are increased in cancer stem cells and samples of prostate cancer.
(2017)
Introduction: Primary tumors of prostate cancer (PCa) are characterized by their cell heterogeneity. Cancer stem cells (CSCs) are tumor cells capable of recapitulate original tumor with their different cell populations. ...
Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer
(Spandidos, 2014)
Cancer stem cells (CSCs) have the ability to self-renew and differentiate to give rise to heterogeneous phenotype of the tumor cells. It is believed that these cells are involved in metastasis, recurrence and therapy ...