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Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
(Karger, 2018-05)
AbstractBACKGROUND/AIMS:Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular ...
Identification of MRP4/ABCC4 as a target for reducing the proliferation of pancreatic ductal adenocarcinoma cells by modulating the cAMP efflux
(American Society for Pharmacology and Experimental Therapeutics, 2019-07)
Pancreatic cancer is one of the most lethal types of tumors with no effective therapy available; is currently the third leading cause of cancer in developed countries; and is predicted to become the second deadliest cancer ...
Papel Da Via Extracelular Amp Cíclico - Adenosina Na Contração Do Músculo Liso Do Trato Respiratório
(Universidade Federal de São Paulo (UNIFESP), 2017-11-30)
Cyclic AMP (cAMP) is a universal intracellular second messenger involved in many biological processes, such as muscle contraction, cell proliferation and gene expression. In the respiratory tract, intracellular cAMP has a ...
Low CyaA expression and anti‐cooperative binding of cAMP to CRP frames the scope of the cognate regulon of Pseudomonas putida
(2021-03)
Although the soil bacterium Pseudomonas putida
KT2440 bears a bona fide adenylate cyclase gene
(cyaA), intracellular concentrations of 30,50-cyclic
adenosine monophosphate (cAMP) are barely detectable.
By using reporter ...
Metallo-β-lactamase-production in meropenem-susceptible Pseudomonas aeruginosa isolates: risk for silent spread
(Instituto Oswaldo Cruz, Ministério da Saúde, 2012-09-01)
The aim of this study was to characterize two metallo-β-lactamases (MBLs)-producing Pseudomonas aeruginosa clinical isolates showing meropenem susceptibility. Antimicrobial susceptibility was assessed by automated testing ...
Implication of Rho-kinase and soluble guanylyl cyclase enzymes in prostate smooth muscle dysfunction in middle-aged rats
(2017-03-01)
Aims: Aging is highly associated with benign prostate hyperplasia (BPH). We investigated here the alterations of the contractile and relaxant machinery in prostates of middle-aged rats, focusing on the Rho-kinase, nitric ...
Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes
(Elsevier, 2013-10)
Background: The peptide mastoparan 7 (MST7) stimulated ATP release in human erythrocytes. We explored intraand extracellular processes governing the time-dependent accumulation of extracellular ATP (i.e., ATPe kinetics). ...
Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
(Wiley Blackwell Publishing, Inc, 2010-04)
We demonstrate that patients with primary Sjögren’s syndrome (pSS) produce functional IgG autoantibodies that interact with the glandular M3 muscarinic acetylcholine receptors (mAChRs). These autoantibodies act as a partial ...
Resistência bacteriana em bacilos Gram-negativos: a importância dos testes fenotípicos
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicina, 2017-11-30)
Gram-negative bacilli are often frequent participants in hospital infections, mainly immunosuppressed patients. In this way, they are very exposed to treatment at-tempts, with beta-lactams being the most used class against ...
Implication Of Rho-kinase And Soluble Guanylyl Cyclase Enzymes In Prostate Smooth Muscle Dysfunction In Middle-aged Rats
(Wiley-BlackwellHoboken, 2017)