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Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease
(2021-09-17)
Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy. Herein, we demonstrate that higher levels ...
Annexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in mice
(2013)
Abstract
Background
Intestinal ischemia/reperfusion (IR) injury is a serious and triggering event in the development of remote ...
Annexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in mice
(BioMed CentralLondres, 2013-03-13)
BACKGROUND:
Intestinal ischemia/reperfusion (IR) injury is a serious and triggering event in the development of remote organ dysfunction, from which the lung is the main target. This condition is characterized by intense ...
Lack of Annexin A6 exacerbates liver dysfunction and reduces lifespan of NPC1- deficient mice
(Elsevier Inc./ American Society for Investigative Pathology, 2020)
Niemann-Pick type C disease (NP-C) is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NP-C disease primarily affects the brain, causing neuronal ...
Effect of annexin-A1 peptide treatment during lung inflammation induced by lipopolysaccharide
(Academic Press Ltd Elsevier B.V. Ltd, 2012-08-01)
Lung endotoxemia is characterized by neutrophil accumulation, increased vascular permeability and parenchymal injury. This can also affect the endogenous pathways that operate in the host to keep inflammation under control. ...
Effect of annexin-A1 peptide treatment during lung inflammation induced by lipopolysaccharide
(Academic Press Ltd Elsevier B.V. Ltd, 2012-08-01)
Lung endotoxemia is characterized by neutrophil accumulation, increased vascular permeability and parenchymal injury. This can also affect the endogenous pathways that operate in the host to keep inflammation under control. ...
Endogenous annexin A1 (AnxA1) modulates early-phase gestation and offspring sex-ratio skewing
(2018-09-01)
Annexin A1 (AnxA1) is a glucocorticoid-regulated anti-inflammatory protein secreted by phagocytes and other specialised cells. In the endocrine system, AnxA1 controls secretion of steroid hormones and it is abundantly ...
Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis
(2016-09-01)
TNF-α is involved in the mechanisms that initiate inflammatory bowel diseases (IBDs). Anti-TNF-α drugs, such as infliximab (IFX), cause non-responsiveness and side effects, indicating the need to investigate alternative ...
Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct
(Federation Amer Soc Exp Biol, 2004-10-01)
Recent interest in the annexin 1 field has come from the notion that specific G-protein-coupled receptors, members of the formyl-peptide receptor (FPR) family, appear to mediate the anti-inflammatory actions of this ...