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Mostrando ítems 11-15 de 15
Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration
(Elsevier Science, 2020-01)
The Wobbler mouse spinal cord shows vacuolated motoneurons, glial reaction, inflammation and abnormal glutamatergic parameters. Wobblers also show deficits of motor performance. These conditions resemble amyotrophic lateral ...
Comparative effects of progesterone and the synthetic progestin norethindrone on neuroprotection in a model of spontaneous motoneuron degeneration
(Pergamon-Elsevier Science Ltd, 2019-09)
The Wobbler mouse has been proposed as an experimental model of the sporadic form of amyotrophic lateral sclerosis (ALS). The administration of natural progesterone (PROG) to Wobbler mice attenuates neuropathology, inhibits ...
Therapeutic effects of progesterone in animal models of neurological disorders
(Bentham Science Publishers, 2013-11-29)
Substantial evidence supports that progesterone exerts many functions in the central and peripheral nervous system unrelated to its classical role in reproduction. In this review we first discussed progesterone effects ...
Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases
(Molecular Diversity Preservation International, 2020-03)
Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases is enhanced. In this brief review, we discuss the ...
Protective effects of the neurosteroid allopregnanolone in a mouse model of spontaneous motoneuron degeneration
(Pergamon-Elsevier Science Ltd., 2017-11)
Amyotrophic lateral sclerosis (ALS) is a devastating disorder characterized by progressive death of motoneurons. The Wobbler (WR) mouse is a preclinical model sharing neuropathological similarities with human ALS. We have ...