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Mostrando ítems 11-20 de 211
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
(Sociedade Brasileira de Química, 2014)
N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels
(Elsevier Science, 2018-01)
In patients with epilepsy, anxiety and depression are the most frequent psychiatric comorbidities but they often remain unrecognized and untreated. We report herein the antidepressant-like activity in two animal models, ...
A novel μ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors
(2012)
BACKGROUND AND PURPOSE The μ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the ...
Evidence for gene duplication in the voltage gated sodium channel gene of Aedes aegypti
(Oxford University Press, 2013)
Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil
(American Society of Tropical Medicine and Hygiene, 2009)
Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers: Ion conduction and gating properties
(1989)
Squid optic nerve sodium channels were characterized in planar bilayers in the presence of batrachotoxin (BTX). The channel exhibits a conductance of 20 pS in symmetrical 200 mM NaCI and behaves as a sodium electrode. The ...
Pyrethroid resistance is associated with a kdr‐type mutation (L1014F) in the potato tuber moth Tecia solanivora
(Pest Management Science, 2018)
Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus
(2002)
The ability of neurons to fire rapid action potential relies on the expression of voltage-gated sodium channels; the onset of the transcription of genes that encode these channels occurs during early neuronal development. ...