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Design, synthesis and evaluation of cholinesterase hybrid inhibitors using a natural steroidal alkaloid as precursor
(Academic Press Inc Elsevier Science, 2021-06-11)
To date, Alzheimers disease is the most alarming neurodegenerative disorder worldwide. This illness is multifactorialin nature and cholinesterase inhibitors have been the ones used in clinical treatments. In this context,many ...
Síntese, avaliação farmacológica e estudos computacionais de dímeros de tacrina
(Universidade Federal de Minas GeraisUFMG, 2014-03-14)
This work presents the synthesis of fifteen new tacrine dimers and results for Ki, IC50, kinetic mechanism and molecular docking analysis in relation to cholinesterases; and the assessment results of the antitumorigenic ...
Tacrina análogos: síntese, derivatização, bioatividade e fotofísica de sistemas heterocíclicos híbridos
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2023-01-27)
This thesis presents the results related to the synthesis, structural characterization and evaluation of the in vitro enzymatic inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of novel series of ...
Produtos naturais como candidatos a fármacos úteis no tratamento do mal de Alzheimer
(2004-07-01)
Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms ...
Produtos naturais como candidatos a fármacos úteis no tratamento do mal de Alzheimer
(2004-07-01)
Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms ...