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Melatonin treatment combined with TGF-β silencing inhibits epithelialmesenchymal transition in CF41 canine mammary cancer cell line
(2020-01-01)
Background: Mammary cancer is the most prevalent type of cancer in female dogs. The main cause of mortality is the occurrence of metastasis. The metastatic process is complex and involves the EpithelialMesenchymal Transition ...
Spred2 inhibits TGF-β1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
(2010)
TGF-β1 is a potent inductor of malignance in cancer cells. TGF-β1 stimulates the expression of extracellular matrix degrading proteases, cell migration and it is also involved in the epithelial-mesenchymal transition (EMT). ...
Association of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell lines overexpressing Egr-1
(Spandidos Publications, 2014)
The present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARFlevels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification ...
Sex differences in the pituitary transforming growth factor-beta1 (TGF-beta1) system: studies in a model of resistant prolactinomas
(Endocrine Soc, 2013-09-05)
Dopamine and estradiol interact in the regulation of lactotroph cell proliferation and prolactin secretion. Ablation of the dopamine D2 receptor gene (Drd2 / ) in mice leads to a sexually dimorphic phenotype of hyperprolactinemia ...
TGF-b1 and TGF-bRII are independent prognostic markers in invasive ductal breast carcinomas
(Amer Assoc Cancer Research, 2009-05-01)
Absence of transforming growth factor-beta type II receptor is associated with poorer prognosis in HER2-negative breast tumours
(Oxford University Press, 2014)