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The Essential, Ubiquitous Single-Stranded DNA-Binding Proteins
(2021-01-01)
Maintenance of genomes is fundamental for all living organisms. The diverse processes related to genome maintenance entail the management of various intermediate structures, which may be deleterious if unresolved. The most ...
The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii
(Frontiers in Bioscience, 2016-05)
Toxoplasma gondii is an apicomplexan parasite of medical and veterinary importance which causes Toxoplasmosis in humans. Great effort is currently being devoted towards the identification of novel drugs capable of targeting ...
When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response
(Elsevier, 2020)
Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response ...
Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells
(Elsevier Science, 2008-11)
Fludarabine (FLU), an analogue of adenosine, interferes with DNA synthesis and inhibits the chain elongation leading to replication arrest and DNA double strand break (DSB) formation. Mammalian cells use two main pathways ...
Current understanding of RAD52 functions: Fundamental and therapeutic insights
(Molecular Diversity Preservation International, 2020-03)
In this Special Issue, we would like to focus on the various functions of the RAD52 helicase-like protein and the current implications of such findings for cancer treatment. Over the last few years, various laboratories ...
Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks
(Public Library of Science, 2016-01-14)
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks ...