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Mostrando ítems 11-20 de 553
Immunoassay platform with surface-enhanced resonance Raman scattering for detecting trace levels of SARS-CoV-2 spike protein
(2022-07-01)
The early diagnosis of Coronavirus disease (COVID-19) requires either an accurate detection of genetic material or a sensitive detection of viral proteins. In this work, we designed an immunoassay platform for detecting ...
Targeting SARS-CoV2 spike protein receptor binding domain by therapeutic antibodies
As the number of people infected with the newly identified 2019 novel coronavirus (SARSCoV2) is continuously increasing every day, development of potential therapeutic platforms is
vital. Based on the comparatively high ...
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
(2023)
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation ...
Leaving no stone unturned: Allosteric targeting of SARS-CoV-2 Spike protein at putative druggable sites disrupts human angiotensin-converting enzyme interactions at the receptor binding domain.
The systematic entry of SARS-CoV-2 into host cells, as mediated by its Spike (S) protein, is
highly essential for pathogenicity in humans. Hence, targeting the viral entry mechanisms
remains a major strategy for COVID-19 ...
Expression, purification and characterization of S542-931 and RBD330-524 from spike protein of SARS-Cov-2
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2021)
Fragment production of the spike protein from SARS-CoV-2 in insect cells for the development of serological diagnosis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2021)
Dynamics of the ACE2–SARS‐CoV‐2/ SARS‐CoV spike protein interface reveal unique mechanisms
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major public health concern.A handful of static structures now
provide molecular insights ...
Recent advances in SARS-CoV-2 Spike protein and RBD mutations comparison between new variants Alpha (B.1.1.7, United Kingdom), Beta (B.1.351, South Africa), Gamma (P.1, Brazil) and Delta (B.1.617.2, India)
(2021-09-01)
New variants of SARS-CoV-2 Alpha (B.1.1.7); Beta (B.1.351) Gamma (P.1) and Delta (B.1.617.2) quickly spread in the UK, South Africa, Brazil and India, respectively. To address whether mutations in SARS-CoV-2 RBD spike ...
Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru
(Springer, 2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries. However, most studies in Peru have focused on Lima, the capital city, without ...
Structural models of human ACE2 variants with SARS-CoV-2 Spike protein for structure-based drug design
Emergence of coronaviruses poses a threat to global health and economy. The current outbreak
of SARS-CoV-2 has infected more than 28,000,000 people and killed more than 915,000. To date,
there is no treatment for coronavirus ...