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Chagas disease pharmacotherapy and its chemical structure activity relationship
(2017-01-01)
Therapeutic arsenal currently available for Chagas disease is restricted in only two drugs, nifurtimox and benznidazole, since 1960s and 1970s, respectively. Despite the efforts to develop new drugs, until now, no new drugs ...
Electronic descriptors for the antimalarial activity of sulfonamides
(2016-08-01)
As an interesting class of materials for designing new antimalarial drugs, sulfonamides have shown potential for several pharmacological applications. In this study, multivariate data analyses were employed to correlate ...
A structure-activity relationship study of quinone compounds with trypanocidal activity
(Elsevier B.V., 2014)
Insights on the structure-activity relationship of peptides derived from Sticholysin II
(Wiley-Blackwell, 2018-09-01)
Sticholysin II (StII) is a pore-forming actinoporin from the sea anemone Stichodactyla helianthus. A mechanistic model of its action has been proposed: proteins bind to cell membrane, insert their N-termini into the lipid ...
Structure-activity relationships of neuroactive steroids acting on the GABAA receptor
(Bentham Science Publishers, 2009-12)
The term "neuroactive steroid" (NAS) refers to steroids which, independent of their origin, are capable of modifying neural activities. These steroids positively or negatively modulate the function of members of the ...
Relation between antioxidant activity and electronic structure of Phenols
(Wiley-Blackwell, 2003-11-05)
We describe a new physicochemical descriptor of the antioxidant activity of phenols, the energy difference between the two highest occupied molecular orbitals, which we believe will improve quantitative structure-activity ...
Relation between antioxidant activity and electronic structure of Phenols
(Wiley-Blackwell, 2003-11-05)
We describe a new physicochemical descriptor of the antioxidant activity of phenols, the energy difference between the two highest occupied molecular orbitals, which we believe will improve quantitative structure-activity ...